Section 1. Introduction
Section 2. RPL of immune etiologies1. Autoimmune etiologies focusing antiphospholipid antibody2. ANA related conditions3. Celiac disease and RPL/RIF4. NK cell pathology and RF; NK cell level, NK cell cytotoxicity and KIR/HLA-C5. Th cell pathology and RPL; TH1/Th2, Treg/Th17, and others6. B cell pathology and RPL; B cell7. Mast cell pathology and RPL8. Endometrial pathology and RPL9. Infectious diseases that can flare immune responses; Lyme's disease, COVID-19, etc.10. Thrombophilic pathology and RPL11. Alloimmune conditions (NAIT, Rh sensitization)
Section 3. Repeated implantation failures of immune etiologies12. Autoimmune etiologies focusing antiphospholipid antibody13. NK cell pathology and RIF14. Th cell pathology and RIF15. B cell pathology and RIF; Allergy, Asthma and infertility16. Endometrial pathology and RIF17. Thrombophilic condition and RIF
Section 4. Systemic immune etiologies for RIF/RPL18. Ovarian pathology and RIF/RPL19. Endometriosis and RIF/RPL20. ART and RIF/RPL21. Hormonal/metabolic diseases that can cause proinflammatory condition: autoimmune thyroiditis, PCOS, DM, vitamin D deficiency, and homocysteinemia22. Stress induced immune flare in women with RF
Section 5. Treatment modalities23. Immunotherapy24. Anti-coagulant25. Hormonal/metabolic26. Reproductive supplements27. Vitamins: Vitamin C, D, E, Folic acid, vitamin B12, selenium, zinc28. Ovulation boost; DHEA, CoQ10, myoinositol, acaiberry, MACA, ALA, NAC, melatonin29. Anti-inflammatory- LDN (low dose naltrexone), curcumin30. Chinese medicine: Zishen Yutai pill, Shoutai pill
