This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.
Rezensionen / Stimmen
From the reviews:"This book comprehensively covers the polymorphism of genes-encoding pattern recognition receptors (PRRs) .. The book is intended for immunologists, cancer researchers, cardiologists, epidemiologists, microbiologists, and geneticists, as well as PhD, graduate, and undergraduate students of biomedical faculties and their lecturers. This is a unique book that analyzes the field of PRR genomics and its practical applications. . This book will be quite useful for a very wide audience." (Omer Iqbal, Doody's Book Reviews, March, 2014)
Sprache
Verlagsort
Zielgruppe
Für Beruf und Forschung
Research
Illustrationen
1
1 s/w Abbildung, 1 farbige Abbildung
XI, 185 p.
Dateigröße
ISBN-13
978-3-0348-0688-6 (9783034806886)
DOI
10.1007/978-3-0348-0688-6
Schweitzer Klassifikation
The Biology of Toll-like Receptors and NOD-like Receptors: Toggles of Inflammation.- Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword.- Structural Genomic Variation in Toll-Like Receptor 4 and Cancer.- Structural Genomic Variation in Other Toll-like Receptors and Cancer.- Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer.- Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer.- Structural Genomic Variation in NOD-Like Receptors and Cancer.- Structural Genomic Variation in Pattern Recognition Receptors and Cardiovascular Diseases.- Hot Spots In the Field: Where Should We Go.
