Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging.
This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability.
- A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects
- Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability
- Contains applications of genome instability research and outcomes for human disease
- Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair
Auflage
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Illustrationen
Approx. 300 illustrations (200 in full color)
Dateigröße
ISBN-13
978-0-323-85680-5 (9780323856805)
Schweitzer Klassifikation
1. Genome stability: An evolutionary perspective
Part I Genome instability of viruses2. Genetic instability of RNA viruses3. Genome instability in DNA viruses
Part II Genome instability in bacteria and archaea4. Genome instability in bacteria and archaea: Strategies for maintaining genome stability5. Genome instability in bacteria: Causes and consequences6. CRISPR - Bacterial immune system
Part III Genome stability of unicellular eukaryotes7. From micronucleus to macronucleus: Programmed DNA rearrangement in ciliates is regulated by non-coding RNA molecules8. Homologous recombination and nonhomologous end-joining repair in yeast
Part IV Genome stability in multicellular eukaryotes9. Meiotic and mitotic recombination: First in flies10. Genome stability in Drosophila: Mismatch repair and genome stability11. Genome stability in Caenorhabditis elegans12. Plant genome stability-General mechanisms13. Genetic engineering in plants using CRISPRs
Part V Genome stability in mammals14. Cell cycle control and DNA-damage signaling in mammals15. The role of p53/p21/p16 in DNA damage signaling and DNA repair16. Roles of RAD18 in DNA replication and post-replication repair (PRR)17. Base excision repair and nucleotide excision repair18. DNA mismatch repair in mammals19. Repair of double-strand breaks by nonhomologous end joining; Its components and their function20. Homologous recombination in mammalian cells: From molecular mechanisms to pathology21. Telomere maintenance and genome stability22. Chromatin, nuclear organization and genome stability in mammals23. Role of DNA mthylation in genome stability24. Non-coding RNAs in genome integrity
Part VIHuman diseases associated with genome instability25. Human diseases associated with genome instability26. Cancer and genomic instability27. Epigenetic regulation of the cell cycle & DNA-repair in cancer28. Genomic instability and aging: Causes and consequences29. The DNA damage response and neurodegeneration: Highlighting the role of the nucleolus in genome (in)stability
Part VII Effect of environment on genome stability30. Diet and nutrition31. Chemical carcinogens and their effect on genome and epigenome stability32. Modern sources of environmental ionizing radiation exposure and associated health consequences
Part VIII Bystander and transgenerational effects: Epigenetic perspective33. Sins of fathers through a scientific lens: Transgenerational effects34. Radiation and chemical induced genomic instability as a driver for environmental evolution35. Transgenerational genome instability in plants36. Methods for the detection of DNA damage37. Conserved and divergent features of DNA repair. Future perspectives in genome stability research38. Off-target effects in genome editing
