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This book presents the current state of knowledge regarding the ability of Helicobacter pylori to colonize the gastrointestinal tract, the global epidemiology of H. pylori infection, transmission routes, the pathophysiology of H. pylori-related gastroduodenal and other diseases, diagnosis and treatment methods, guidelines for eradication, antibiotic resistance, the reinfection and recrudescence rate after H. pylori eradication, the effect of H. pylori and its eradication on the gastric microbiota and animal models of H. pylori or related Helicobacter infection. The aim is to equip readers around the world with the understanding required in order to implement effective methods of H. pylori eradication and to enhance clinical outcomes for patients. In addition, readers can understand the interaction between H. pylori and other gut microbiota during chronic infection and after H. pylori eradication. The text is clearly written and is complemented by many helpful illustrations. This book will be a great asset in clinical practice for all practitioners who are involved in caring for patients with H. pylori-related diseases or have an interest in the subject. It will also be a useful source of information for medical students and for intelligent laypeople seeking information on H. pylori.
Part I Epidemiology.- 1 Prevalence and Transmission Routes of H. pylori.- Part II Pathophysiology.- 2 Gastric Colonization by H. pylori.- 3 Immunological Reactions on H. pylori Infection.- 4 Change of Acid Secretions, Ghrelin and Leptin, by H. pylori.- 5 H. pylori Virulence Factors: Toxins (CagA, VacA, DupA, OipA, IceA).- 6 H. pylori Virulence Factors: Genetic Polymorphism and Disease.- 7 Host Factor: Genetic Polymorphism.- Part III Diagnosis.- 8 Serology.- 9 Histopathologic Diagnosis of H. pylori Infection and Associated Gastric Diseases.- 10 Culture.- 11 Urea Breath Test.- 12 H. pylori Stool Antigen Test.- 13 Specific Conditions: Children.- 14 Specific Conditions: Diagnosis of H. pylori Infection in Case of Upper Gastrointestinal Bleeding.- Part IV Symptom.- 15 Symptoms of Acute and Chronic H. pylori Infection.- Part V Disease.- 16 Synopsis of H. pylori-Associated Diseases.- 17 Atrophic Gastritis and Intestinal Metaplasia.- 18 Functional Dyspepsia.- 19 Peptic Ulcer.- 20 Gastric Extranodal Marginal Zone B-Cell Lymphoma of MALT.- 21 Gastric Cancer: Synopsis and Epidemiology of Gastric Cancer.- 22 Gastric Cancer: Genetic Alternations Induced by H. pylori Infection: The Role of Activation- Induced Cytidine Deaminase.- 23 Gastric Cancer: Epigenetic Mechanisms: Aberrant DNA Methylation and Dysregulation of MicroRNA.- 24 Gastric Cancer: H. pylori and Macrophage Migration Inhibitory Factor.- 25 Gastric Cancer: Epithelial Mesenchymal Transition.- 26 Gastric Cancer: ABO Blood Type.- 27 Gastric Cancer: First Relatives of Gastric Cancer.- 28 H. pylori Infection-Negative Gastric Cancer.- 29 Gastroesophageal Reflux Disease.- 30 NSAID-Induced Gastropathy and H. pylori Infection.- 31 Extraintestinal Manifestations of H. pylori Infection: H. pylori- Associated Iron-Deficiency Anemia.- 32 Extraintestinal Manifestations of H. pylori Infection: Idiopathic Thrombocytopenic Purpura.- 33 Extraintestinal Manifestations of H. pylori Infection: Heart Disease.- 34 Extraintestinal Manifestations of H. pylori Infection: Asthma and Allergic Disorders.- Part VI Antibiotic Resistance.- 35 Synopsis of Antimicrobial Resistance.- 36 Clarithromycin.- 37 Amoxicillin.- 38 Fluoroquinolone.- 39 Metronidazole.- Part VII Treatment.- 40 Synopsis of Antibiotic Treatment.- 41 Triple Therapy.- 42 Quadruple Therapy.- 43 Sequential Therapy.- 44 Concomitant Therapy and Hybrid Therapy.- 45 Tailored Therapy Based on Antibiotic Resistance.- 46 Levofloxacin/Moxifloxacin or Rifabutin-Based Triple Therapy.- 47 Probiotics.- 48 Treatment Guidelines.- 49 Gastric Cancer Screening.- 50 Recrudescence and Reinfection After H. pylori Eradication Treatment.- Part VIII Consequences of H. pylori Eradication.- 51 Peptic Ulcer Disease.- 52 Atrophic Gastritis and Intestinal Metaplasia.- 53 Gastric Cancer.- 54 Extraintestinal Manifestations Depending on Sex and Age.- Part IX The Effect of H. pylori Infection and its Eradication on the Gastric Microbiota.- 55 The Effect of H. pylori Infection on theGastric Microbiota.- 56 The Effect of H. pylori Eradication on the Gastric Microbiota.- Part X Animal Model.- 57 Animal Models of H. pylori Infection.
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