In 1983 Graham Hughes described a syndrome in which the blood has a tendency to clot. Hughes syndrome is at the root of diverse conditions such as stroke, leg vein thrombosis and recurrent abortion.
Hughes Syndrome
addresses the complete range of features produced by this common disorder, which is also known as antiphospholipid syndrome. The condition can affect any organ, and is treated using commonly available drugs including low-dose aspirin and warfarin. This timely book fulfils the need for a cross-disciplinary clinical textbook and contains contributions from the leading international authorities.
Hughes Syndrome
should be read by anyone who might have a clinical or scientific interest in this condition: rheumatologists, haematologists, obstetricians and neurologists.
Sprache
Verlagsort
Verlagsgruppe
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Dateigröße
ISBN-13
978-1-4471-3666-8 (9781447136668)
DOI
10.1007/978-1-4471-3666-8
Schweitzer Klassifikation
Section 1: Clinical Aspects.- 1 Hughes Syndrome: History.- 2 Antiphospholipid Syndrome: General Features.- 3 Hemocytopenias in Antiphospholipid Syndrome.- 4 Cardiac Manifestations in the Antiphospholipid Syndrome.- 5 Cerebral Disease in the Antiphospholipid Syndrome.- 6 Skin Manifestations of the Antiphospholipid Syndrome.- 7 Kidney Disease in the Antiphospholipid Syndrome.- 8 The Ear and Antiphospholipid Syndrome.- 9 The Eye in the Primary Antiphospholipid Syndrome (Hughes Syndrome).- 10 Pulmonary Hypertension and Antiphospholipid Antibodies.- 11 Off the Beaten Track - a Clinician's View.- 12 The Primary Antiphospholipid Syndrome.- 13 Catastrophic Antiphospholipid Syndrome.- 14 Infections and Antiphospholipid Antibodies.- 15 Drug-induced Antiphospholipid Antibodies.- 16 Antiphospholipid Antibodies and Antiphospholipid Syndromes in Children.- 17 Antiphospholipid Antibodies as a Risk Factor for Atherosclerosis.- 18 Accelerated Atherosclerosis in Antiphospholipid Syndrome.- 19 Pregnancy Loss and Antiphospholipid Antibodies.- 20 Imaging of Microemboli in Antiphospholipid Syndrome.- Section 2: Laboratory Investigation.- 21 Anticardiolipin Testing.- 22 Lupus Anticoagulant Measurement.- 23 Lupus Anticoagulants: Mechanistic and Diagnostic Considerations.- 24 Measurement of Anti-?2-glycoprotein I Antibodies.- 25 Antiprothrombin Antibodies.- 26 Antiphospholipid Antibody-negative Syndrome - Other Phospholipids.- Section 3: Basic Aspects.- 27 Vascular Pathology of the Antiphospholipid Antibody Syndrome.- 28 Placental Pathology in Antiphospholipid Antibody Syndrome.- 29 Mechanisms of Thrombosis in the Antiphospholipid Syndrome: Binding to Platelets.- 30 Interaction of Antiphospholipid Antibodies with Endothelial Cells.- 31 The Influence of Antiphospholipid Antibodies on theProtein C Pathway.- 32 Tissue Factor Pathway in Antiphospholipid Syndrome.- 33 Plasminogen Activation and Fibrinolysis in the Antiphospholipid Syndrome.- 34 Interaction Between Antiphospholipid Antibodies and Eicosanoids.- 35 Family Studies and the Major Histocompatibility Complex.- 36 Monoclonal Antiphospholipid Antibodies and their Sequences.- 37 Apoptosis and Antiphospholipid Antibodies.- 38 The Contribution of Experimental Models to our Understanding of Etiology, Pathogenesis and Novel Therapies of the Antiphospholipid Syndrome.- Section 4: Therapy.- 39 Management of Thrombosis in the Antiphospholipid Syndrome.- 40 The Management of Antiphospholipid Syndrome in Pregnancy.- 41 Management of Thrombocytopenia in Hughes Syndrome.- 42 The Role of Antiphospholipid Syndrome in Critical Illness.- 43 Infertility, Oral Contraceptive Pills, Hormone Replacement Therapy and the Antiphospholipid Antibody Syndrome.- Section 5: Differential Diagnosis.- 44 Antiphospholipid Syndrome: Differential Diagnosis.- Section 6: Prognosis.- 45 Prognosis and Future Directions.
