Polymeric Micelles for Drug Delivery provides a comprehensive overview on the synthesis, characterization and application of polymeric micelles in drug delivery applications. The use of nanomedicines and carriers, such as polymeric micelles, has made it possible to deliver drugs, genes and therapeutic agents to localized disease sites to maximize clinical benefit while limiting unwanted side effects. This book thoroughly reviews the development and application of polymeric micelles for drug delivery, covering various polymer types and the synthesis, characterization and pharmacokinetics of different micelles.
Subsequent chapters go on to look at the range of drug delivery applications of polymeric micelles - such as mucosal and transdermal - and the assorted stimuli-responsive micelles available. The book concludes with an important analysis of the environmental and regulatory aspects associated with micelle development and clinical translation.
- Explores how polymeric micelles can be utilized in a range of different drug delivery approaches, from traditional oral delivery to ocular and dermal delivery
- Describes the various polymer types used in the synthesis and characterization of polymeric micelles
- Covers recent advances in polymeric micelles, such as drug co-delivery, triblock polymeric micelles, delivery of genetic materials, and more
Reihe
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Illustrationen
Approx. 200 illustrations (50 in full color)
Dateigröße
ISBN-13
978-0-323-88629-1 (9780323886291)
Schweitzer Klassifikation
Part A: Synthesis and characterization of polymeric micelles for drug delivery1. Polymeric micelles: pre¿ cis for past, present, and future2. Various polymers in the development of polymeric micelles3. Solubility enhancement and drug release mechanism of polymeric micelles4. Polymeric micellar nanomedicine for enhanced permeability and retention effect 5. Polymeric micelles for oral drug delivery6. Polymeric micellar nanocarriers: topical treatment of inflammatory diseases
Part B: Application of polymeric micelles in drug delivery7. Polymeric micelles in dermal and transdermal drug delivery8. Polymeric micelles as delivery systems for anticancer immunotherapy9. Polymeric micelles for drug delivery in oncology 10. Surface engineering of polymeric micelles for imparting multifunctionality11. Cellular interaction of polymeric micelles in targeted drug delivery systems: the road from tissue to cell
Part C: Stimuli-responsive polymeric micelles for drug delivery12. pH-responsive polymeric micelles for drug delivery13. Enzyme-responsive polymeric micelles for drug delivery applications14. Light- and temperature-responsive polymeric micelles for drug delivery15. Exogenous stimuli 16. Dual-responsive polymeric micelles for drug delivery
Part D: Recent advances in polymeric micelles17. Polymeric micelles for drug codelivery18. Nose-to-brain delivery19. The application of a drug 20. Polymeric micelles with cleavable links for drug delivery21. Block copolymer micelles as long-circulating drug delivery vehicles22. Triblock polymeric micelles as an emerging nanocarrier for drug delivery
Part E: Environmental and regulatory aspects23. Biological toxicity and environmental hazards associated with polymeric micelles24. Clinical translation of polymeric micelles into market25. Regulatory pathways and prospects for polymeric micelles
