Adverse Drug Effects

Preface ix
Introduction xi
PART 1 THE SCIENCE OF ADVERSE DRUG EFFECTS
Chapter 1 Pharmacokinetic effects - absorption and distribution 3
Chapter 2 Pharmacokinetic effects - metabolism and excretion 24
Chapter 3 Pharmacodynamics and receptors 37
Chapter 4 Pharmacodynamics, enzymes, ion channels and carriers 44
Chapter 5 Idiosyncratic effects and drug allergy 52
Chapter 6 Client groups 67
Chapter 7 Gastro-intestinal and hepatic effects 90
Chapter 8 Renal effects 111
Chapter 9 Cardiovascular and respiratory effects 128
Chapter 10 Neurological, sensory and endocrine effects 150
Chapter 11 Psychological effects 172
Chapter 12 Effects on the skin and musculoskeletal system 186
Chapter 13 Effects on the reproductive system and sexuality 202
Chapter 14 Drug resistance 215
PART 2 THE ART OF ADVERSE DRUG EFFECTS
Chapter 15 Nurse administration and prescribing 227
Chapter 16 Ethics of drug development and testing 241
Chapter 17 Compliance, patient education and empowerment 252
Chapter 18 Complementary therapy -- Debrae Ward-Walsh 268
PART 3 THE PRACTICE -- 12 CASE STUDIES
Chapter 19 Assessment issues 287
Chapter 20 Drug interactions 297
Chapter 21 Drug misuse 310
Chapter 22 Empowerment 323
Abbreviations and Glossary 336
Index 341