Cytokines of the Lung

Introduction -- Preface -- Contributors -- Part I MITOGENIC CYTOKINES -- 1. Platelet-Derived Growth Factor /James P. Fabisiak and Jason Kelley -- I. Introduction -- II. Protein Structure -- III. Gene Structure, Organization, and Processing -- IV. PDGF Receptors -- V. Biological Properties of PDGFs -- VI. Cellular Sources of PDGF -- VII. Regulation of PDGF -- VIII. PDGF in Lung Disease -- IX. Conclusions -- References -- 2. Fibroblast Growth Factors /David Moscatelli -- I. Introduction -- IL History of FGFs -- III. Structural Properties -- IV. FGF Receptors -- V. Interaction with Extracellular Matrix -- VI. Biological Properties -- VIL The Role of FGFs in Tumor Formation -- VIII. FGFs in Lung Biology -- References -- 3. Insulin-Like Growth Factors /Alan D. Stiles, Billie M. Moats-Staats, and George Z. Retsch-Bogart -- I. Introduction -- II. IGF Peptides -- III. IGF Genes and Transcripts -- IV. IGF Receptors -- V. IGF-Binding Proteins -- VI. Actions of IGFs -- VIL Role of IGFs in Fetal Growth -- VIII. Role of IGFs in Postnatal Growth -- IX. IGFs and Lung -- X. Summary -- References -- 4. Transforming Growth Factor-,8 /Jason Kelley -- I. Introduction -- II. The TGF-ss Family of Proteins -- III. Biosynthesis of TGF-ss -- IV. Gene Structure of TGF-,Bs -- V. Control of TGF-ss Gene Expression -- VI. Autoinduction of TGF-ss Gene Expression -- VII. Activation of TGF-ss Protein -- VIII. Receptors for TGF-ss -- IX. Signaling Pathways for TGF-ss -- X. TGF-ss as a Mitogen -- XL Antiproliferative Effects of TGF-ss -- XII. TGF-ss and Extracellular Matrix -- XIII. Interactions Between TGF-ss and Other Cytokines -- XIV. TGF-ss and the Immune System -- xv. TGF-ss in Monocyte-Macrophages, Granulocytes, and Mast Cells -- XVI. TGF-ss in Fibroblasts -- XVII. Assays for TGF-ss -- XVIII. TGF-ss in Lung -- XIX. TGF-ss in Remodeling and Fibrosis -- xx. Future Directions -- References -- 5. Transforming Growth Factor-a and Epidermal Growth Factor /David K. Madtes -- I. Introduction -- II. The Growth Factor Pr