Neuronal Information Transfer

List of ParticipantsPrefaceOpening Address Text ReferencesPart I Biogenic Amine Systems Genetic, Structural, and Molecular Mechanisms Governing the Long-Term Regulation of Tyrosine Hydroxylase, a Neurotransmitter Synthesizing Enzyme in the Brain Neurotransmitter Synthesizing Enzymes in the Brain Long-Term Regulation of Brain Tyrosine Hydroxylase Summary References Regulations of Activity of the Nigrostriatal Dopaminergic Systems Introduction Influences of Substance P and GABAergic Neurons on the Activity of the Nigrostriatal Dopaminergic Pathway Imbalance between the Activity of the Two Nigrostriatal Dopaminergic Pathways The Release of Dopamine from Dopaminergic Dendrites Role of the Dendritic Release of Dopamine in the Control of the Activity of the Nigrostriatal Dopaminergic Neurons Concluding Remarks References Regulation of Sensitivity to ß-Adrenergic Stimulation in the Rat Pineal Introduction Variation in Sensitivity of Induction Receptors and Adenylate Cyclase Cyclic AMP and Phosphodiesterase Protein Kinase References Molecular Properties and Regulation of Alpha- and Beta-Adrenergic Receptors Introduction Identification of a- and ß-Adrenergic Receptors by Radioligand Binding Desensitization of Adrenergic Receptors Receptor Supersensitivity Summary and Conclusions References Biochemical Characterization of Neurotransmitter Receptors in the Brain Introduction Methodological Principles The Dopamine Receptor Evidence for a Two-State Model of Neurotransmitter Receptors ReferencesPart II Cholinergic System The Cholinergic Electromotor System of Torpedo: Recent Biochemical and Morphological Findings Introduction Developmental Studies Tissue Fractionation Studies of Synaptic Vesicle Dynamics Conclusions References Studies on the Mechanism of Acetylcholine Release in Mammalian Tissues Introduction Amount of ACh in a Vesicle and in a Quantum Specificity of ACh Release and Storage Turnover of ACh in Nerve Terminal Pools Tissue Differences in ACh Storage and Release or Their Control References Nerve Excitability: From Descriptive Phenomenology to Molecular Interpretation Introduction: Early Theories of Axonal Conduction and Synaptic Transmission Alternative Interpretation of the Function of ACh in Excitable Membranes as a Result of Biochemical and Physiochemical Analyses A Model Integrating Biochemical, Biophysical, and Thermodynamic Data The Role of ACh at Synaptic Junctions References Acetylcholine Receptor-Mediated Ion Flux in Electroplax Membrane Microsacs Text References Acetylcholine Receptor: Accelerated Dissociation of Receptor-Ligand Complexes Introduction Methods Results Discussion References Elementary Chemical Reactions of Acetylcholine with Receptor and Esterase: Relationship to Neuronal Information Transfer Introduction Localization of Acetylcholine Receptor and Acetylcholinesterase Do Receptor and Esterase Compete for Acetylcholine? Kinetic Analyses Acetylcholinesterase Acetylcholine Receptor Comparisons between Competitive and Sequential Reactions of Acetylcho-line at the Synapse ReferencesPart III Amino Acid Systems Roles of GABA in Neurons in Information Processing in the Vertebrate CNS Introduction Disinhibition as a Major Organizing Principle GABA Neurons and Problems of Functional Coordination in the Nervous System Identifying GABA-Releasing Neurons in Regions of the Vertebrate CNS