The tumors of the brain similar to other pathological changes of that particular organ claim for a separate position in scientific medicine regarding biology, morphology, features of clinical manifestation, diagnostics and therapy. During the past years due to rapid progress in basic neurosciences and medical biotechnics the situation of the neuroclinician in front of brain tumors has been dramatically changed. The prerequisites for early and accurate diagnosis as well as for successful treatment also of malignant neoplasms have increased and remarkably improved. At the same time the information necessary for an appropriate pragmatic use of the available cognitive methods and therapeutic means increased along the same scale and is permanently being critically modified or changed due to fundamental new insights which come up in always shorter intervals. These facts necessitate the preparation of publications in which the state of the art is presented in possible completeness, systematic order and proper disposability for rational management and therapeutic strategies.
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ISBN-13
978-3-7091-8876-7 (9783709188767)
DOI
10.1007/978-3-7091-8876-7
Schweitzer Klassifikation
1 Pathology of Human Intracranial Neoplasia.- I. Introduction.- II. Basic Principles of Neurooncology.- III. Classification and Grading.- IV. Epidemiology.- V. Special Neurooncology.- References.- 2 Neurosurgery of Malignant Brain Tumors.- I. Introduction and Historical Retrospect.- II. General Neurosurgery.- III. Special Neurosurgery.- IV. Significance of the Surgical Measures and Critical Assessment of Their Results.- References.- 3 Neurosurgical Interventions for Intracranial Metastases.- Data on the Morbidity.- Indications for Operation.- Operative Technique.- Results of Operation.- References.- 4 Stereotactic Biopsy and Technique of Implantation (Instillation) of Radionuclids.- 1. Biopsy for Differentiation of Intracranial Processes and Optimization of Therapy.- 2. Curie (Brachy-Curie) Therapy (BCiT).- 3. Techniques of Implantation of Radionuclides.- 4. Results of BCiT.- 5. New Results of BCiT.- 6. The Place of BCiT in the Treatment Plan.- 7. Indications for Curie (Brachy-Curie) Therapy and Combined Radiotherapy.- References.- 5 Radiation Therapy of Brain Tumors.- 1. Introduction.- 2. Fundamentals of Radiotherapy.- 3. Radiotherapeutic Technique.- 4. Special Radiotherapy of Brain Tumors.- 5. Complications of Radiotherapy.- References.- 6 Principles of Chemotherapy in Brain Neoplasia.- I. Introduction.- II. Basic Principles.- III. Specific Therapeutic Agents.- IV. Practical Pharmacologic Considerations.- V. Histopathologic Effects of Brain Tumor Chemotherapy.- VI. Modes of Drug Administration.- VII. Blood-Brain Barrier Disruption (BBBD).- VIII. Drug Rescue Techniques.- IX. Radiation Sensitizers.- X. Monoclonal Antibodies.- XI. Special Cases in CNS Tumor Therapy.- XII. Experimental Drugs.- XIII. Drug Protocols.- XIV. Conclusion.- References.- 7 Results of Chemotherapyof Malignant Brain Tumors in Adults.- 1. Diagnostics.- 2. Results and Indications of Chemotherapy.- 3. Summary and Conclusions.- References.- 8 Malignant Brain Tumors in Children.- Clinical Features.- Symptoms and Signs of Supratentorial Tumors.- Symptoms and Signs of Infratentorial Tumors.- Diagnostic Tests.- Neuroradiological Investigations.- Principles of Pediatric Neurooncology.- Evaluation of Therapeutic Results.- The Blood-Brain Barrier (BBB).- Iatrogenic BBB Disruption.- Treatment of Brain Tumors by Interferon.- Cytostatic Drugs.- Side-Effects of Combined Therapy.- Special Pediatric Neurooncology.- Clinical Remarks on Tumors of the Pineal Region.- References.
