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The Multiple Inert Gas Elimination Technique (MIGET) is a complex methodology involving specialized gas chromatography and sophisticated mathematics developed in the early 1970's. Essentially, nobody possesses knowledge of all its elements except for its original developers, and while some practical and theoretical aspects have been published over the years, none have included the level of detail that would be necessary for a potential user to adopt and understand the technique easily. This book is unique in providing a highly detailed, comprehensive technical description of the theory and practice underlying the MIGET to help potential users set up the method and solve problems they may encounter.
But it is much more than a reference manual - it is a substantial physiological and mathematical treatise in its own right.
It also has a wide applicability - there is extensive discussion of the common biological problem of quantitative inference. The authors
Lastly, the book summarizes the hundreds of research papers published by a number of groups over the decades in a way never before attempted in order to marshal the world's literature on the topic and to provide in one place the wealth of important discoveries, both physiological a
Susan R. Hopkins MD PhD is a Professor of Medicine and Radiology at the University of California, San Diego. For over 30 years she has been studying the lung under conditions of stress: hypoxia, high altitude exercise and lung disease. After receiving her MD degree from Memorial University of Newfoundland, she graduated from the University of British Columbia with a Fellowship in Sports Medicine and a PhD in exercise physiology. Her interest in pulmonary gas exchange led her to UCSD in 1993 to work with Peter Wagner and learn MIGET first-hand, a collaboration which continues to this day. In addition to work in human athletes and patients, she has also explored the relationship between lung structure and gas exchange during exercise in a number of non-human species including monitor lizards, horses and emus, showing that across these divergent species ventilation-perfusion matching is remarkably well preserved. Recent work focuses on the use of functional proton MRI to characterize lung ventilation, perfusion and ventilation-perfusion matching in health and disease. She is an Associate Editor of Applied Physiology Nutrition and Metabolism and the European Journal of Applied Physiology. She also serves on the NIH MEDI study section.
Dr. Peter D. Wagner is Emeritus Distinguished Professor of Medicine & Bioengineering at the University of California, San Diego in La Jolla, CA. After obtaining his M.B., B.S. and B.Sc. (Medicine) degrees from Sydney University in 1968, he did postdoctoral work with Professor John West at UCSD in La Jolla, CA, USA. He then joined the UCSD medical faculty and has remained there to the present time. His research addresses the theoretical and experimental basis of oxygen transport and its limitations in the lungs and skeletal muscles in health and disease. Many years ago, he developed the Multiple Inert Gas Elimination Technique for determining the distribution of ventilati
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