In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ messengers. A wide range of physiological functions are now known to be mediated by them in cells spanning three biological kingdoms from protist, plant to animal. This is the first book devoted entirely to the field. The story behind the emergence of the field is told and followed by comprehensive reviews of the enzymology, regulations and gene structures of ADP-ribosyl cyclases responsible for metabolizing cADPR and NAADP. Also covered is some of the current methodology developed for and widely used in the field. The rest of the book focuses on and details the Ca2+ signaling mechanisms and specific physiological functions of these two messengers in various cellular systems.
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Dateigröße
ISBN-13
978-1-4615-0269-2 (9781461502692)
DOI
10.1007/978-1-4615-0269-2
Schweitzer Klassifikation
Cyclic ADP-Ribose and NAADP A Story of Two Calcium Messengers.- ADP-Ribosyl Cyclases - A Family of cADPR and NAADP Metabolizing Enzymes.- Regulation of Synthesis of cADPR and NAADP.- A Natural History of the Human CD38 Gene.- A Yeast Expression System of High Efficiency for Producing Recombinant Enzymes.- Novel Cycling Assays for cADPR and NAADP.- Pharmacology of Cyclic ADP-Ribose and NAADP Synthesis and Properties of Analogs.- Separate but Interacting Calcium Stores.- Sensitizing Calcium-Induced Calcium Release Role of cADPR as an Endogenous Modulator.- Spatial and Temporal Control of Calcium Signaling by NAADP.- Regulation of Immune Responses by CD38 and cADPR.- Subcellular and Extracellular Trafficking of NAD+ and Cyclic ADP-Ribose: A New Way for Regulating Intracellular Calcium Homeostasis.- The CD38-Cyclic ADP-Ribose Signal System in Pancreatic ß- Cells.- The Role of cADPR and NAADP in T Cell Calcium Signaling and Activation.- Calcium Signaling by cADPR in Cardiac Myocytes.- Cyclic ADP-Ribose and Vasomotor Response.- Coordination of Calcium Signaling by cADPR and NAADP in Pancreatic Acinar Cells.- Calcium and Calcium-Linked Second Messengers are Main Actors in the Maturation and Fertilization of Starfish Oocytes.- ADP-Ribosylation and CD38 Signaling.- Retinoid-Mediated Signaling and CD38 Expression.- Calcium Regulation in Smooth Muscle Through the CD38/Cyclic ADP-Ribose Pathway.- Author Index.
