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This book revolutionizes our understanding of the regulation of the hypothalamic-pituitary-thyroid axis and the homeostasis of the thyroid system, offering a groundbreaking framework for diagnosing and treating hypothyroidism. By challenging conventional approaches, it addresses the pressing need for improved treatment quality, especially for patients experiencing persistent symptoms despite standard levothyroxine therapy.
Delve into a comprehensive exploration of hypothyroidism, from its definition and pathophysiology to patient presentation and endocrine regulation. The chapters illuminate critical topics such as iodine metabolism, thyroid hormone signaling, and the intricacies of the hypothalamic-pituitary-thyroid axis. With contributions from leading experts, this book presents a paradigm shift in clinical care by integrating recent advances in thyroid regulation into practical treatment strategies. Readers will uncover why many patients fail to respond adequately to current treatments and discover innovative approaches to diagnosis and therapy.
Ideal for medical professionals, researchers, clinicians, and specialists interested in thyroid disease, this book is also invaluable for general practitioners and informed patients seeking deeper insights into their condition. Aspiring endocrinologists will find it particularly educational, aligning with curriculum requirements while offering a fresh perspective on thyroid health. With its focus on cutting-edge research and practical applications, this volume is indispensable for anyone dedicated to improving patient care in the field of endocrinology.
Rudolf Hoerman
Formerly Department of General Internal Medicine, Gastroenterology and Endocrinology, Klinikum Lüdenscheid, Lüdenscheid, Germany
Rudolf Hoermann received his MD and PhD from the University of Munich, Germany and is a board certified Internist and Endocrinologist. His training included a fellowship with Harvard University, Boston, USA. During his career he held various positions at leading universities in Germany. He headed the Department of General Medicine, Gastroenterology and Endocrinology at Klinikum Lüdenscheid, a major teaching hospital. He is a member of numerous medical societies.
After retirement, he currently lives at the Sunshine Coast, Australia where as an independent scholar he continues to be involved in research with several institutions, including his former institution and the Universities of Bochum, Germany and Melbourne, Australia. His ongoing interest in thyroidology and extensive experience in basic and clinical research is documented by the authorship or co-authorship of more than 150 articles or reviews in peer-reviewed journals, a dedicated book to thyroid disease, numerous book sections and many international scientific presentations.
Johannes W. Dietrich
Diabetes, Endocrinology and Metabolism Section, Department of Medicine I, St. Josef Hospital, Bochum, Germany
Johannes W Dietrich received his medical education and training at the University of Munich. He is currently the Head of the Diabetes, Endocrinology and Metabolism Section, Department of Medicine I, St. Josef Hospital, Ruhr University of Bochum and of the Diabetes Centre Bochum/Hattingen, Klinik Blankenstein, Hattingen. His interest lies in basic and clinical research in endocrinology with special focus on thyroidology and diabetology. He is also proficient in several programming languages and mathematical modelling. He is a member of multiple international and national societies and the author of more than 150 scientific publications, not including his numerous oral and poster presentations.
1 Hypothyroidism.- 2 Concept of Relational Stability.- 3 Thyroid Physiology.- 4 Introduction to Mathematical Modelling.- 5 Hypothalamic-Pituitary-Thyroid Regulation.- 6 Mechanisms of Heath and Disease.- 7 Approach to the Patient.- 8 Biochemical Thyroid Function Testing.- 9 The New Paradigm for Thyroid Function Diagnosis and Treatment; Conceptual and Technical Barriers to Consistent Outcomes.- 10 Diagnosis of Hypothyroidism.- 11 Treatment of Hypothyroidism.- 12 Special Considerations in the Treatment of Hypothyroidism.
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