Metabolic Inhibitors V4

List of ContributorsPrefaceContents of Other VolumesChapter 1 Allosteric Inhibitors I. Introduction II. Limiting Models for Allosteric Inhibition III. Methods That Probe Mechanisms of Allosteric Inhibition IV. Variation of Allosteric Properties among Source Organisms V. Classes of Allosteric Inhibitors VI. Allosteric Inhibition of Specific Enzymes VII. Allosteric Inhibition in Enzyme Complexes and Membrane Systems References Chapter 2 Amino Acid Hydroxylase Inhibitors I. Introduction II. Properties of the Enzymes III. In Vitro Inhibitors of the Hydroxylases IV. In Vivo Inhibitors of the Hydroxylases V. Indirect Mechanisms of Inhibition VI. Conclusion References Chapter 3 Inhibitors of Amino Acid Activation I. Introduction II. Noncompetitive Inhibitors III. Competitive Inhibitors IV. Conclusion References Chapter 4 Inhibitors of Protein Synthesis I. Introduction II. Protein Biosynthesis III. Inhibitors of Peptide Chain Initiation IV. Inhibitors of Peptide Chain Elongation V. Inhibitors of Peptide Chain Termination VI. Premature Peptide Chain Termination VII. Other Inhibitors VIII. Summary References Chapter 5 Inhibition of Photosynthesis I. Introduction II. The Overall Mechanism of Photosynthesis III. Light-Dependent Reactions of Chloroplast Lamellae IV. Partial Reactions of Photosynthesis in Isolated Chloroplast Lamellae V. Inhibitions of Electron Transport and Phosphorylation in Chloroplast Lamellae VI. Inhibition of the Fixation and Reduction of Carbon Dioxide VII. Photorespiration and the Inhibition of Photosynthesis by Oxygen VIII. Indirect Inhibitions and the Physiological Control of Photosynthesis IX. Conclusion References Chapter 6 Inhibitors of Blood-Clotting Mechanisms I. Introduction II. Inhibitors of Enzyme Action III. Inhibitors of Coagulant Protein Biosynthesis IV. Hereditary Inhibitors V. Acquired Circulating Anticoagulants VI. Fibrinogen Degradation Products VII. Inhibitors of Lipids and Lipoproteins VIII. Inhibitors of Intravascular Coagulation and Thrombosis IX. The Role of Heparin in Blood Coagulation X. Concluding Remarks References Chapter 7 Inhibitors of Fatty Acid Oxidation and the Pathway of Fatty Acid Biosynthesis from Glucose I. Fatty Acid Oxidation II. Inhibition of Pathways of Fatty Acid Synthesis III. Concluding Comments References Chapter 8 Inhibitors of Enzymes of Phospholipid and Sphingolipid Metabolism I. Introduction II. Phospholipid Hydrolases III. Glycosphingolipid Hydrolases IV. Synthesis of the Glycerophosphatides V. Synthesis of Phospho- and Glycosphingolipids VI. Metabolism of the Sphingosine Bases VII. Summary and Conclusions References Chapter 9 Inhibitors and Activators of Enzymes Regulating the Cellular Concentration of Cyclic AMP I. Introduction II. Distribution, Subcellular Location, Purification, and Properties of Adenyl Cyclase and Cyclic AMP Phosphodiesterase III. Regulation of Intracellular Levels of Cyclic AMP IV. Regulation of Cyclic AMP Formation in Cells in Culture V. Adenyl Cyclase and Phosphodiesterase in Relation to Age VI. Role of Lipids in the Activation of Adenyl Cyclase by Hormones VII. Modification of Adenyl Cyclase in Various Physiological and Pathological Conditions VIII. Concluding Remarks References Author Index Subject Index