The GnRH Neuron and its Control

List of Contributors vii

Series Preface xi

Preface xiii

About the Companion Website xv

Part I Historical Introduction to the GnRH Neuron

1 The Framework Upon Which Current Research on the GnRH Neuron and its Control is Built 3

Tony M. PlantandAllan E. Herbison

Part II GnRH Neuron Development

2 Prenatal Development of GnRH Neurons 15

Yufei ShanandSusan Wray

3 Fetal/perinatal Programming Causing Sexual Dimorphism of the Kisspeptin-GnRH NeuronalNetwork 43

Hiroko Tsukamura,Kei-ichiro MaedaandYoshihisa Uenoyama

4 Postnatal Development of GnRH Neuronal Function 61

Ei Terasawa

Part III GnRH Neuron Biology

5 Regulation of GnRH Gene Expression 95

Hanne M. HoffmannandPamela L. Mellon

6 Morphology of the Adult GnRH Neuron 121

Rebecca E. Campbell

7 The Anatomy of the GnRH Neuron Network in the Human 149

Katalin SkrapitsandErik Hrabovszky

8 Electrophysiology of Rodent GnRH Neurons 177

Richard PietandAllan E. Herbison

9 Anatomy and Physiology of GnRH Neurons and Their Control of Pituitary Function in Fish 203

Yoshitaka Oka

Part IV Regulation of GnRH Neuron Function

10 Unveiling the Importance of Glia and Vascular Endothelial Cells in the Control of GnRH NeuronalFunction 227

Vincent PrevotandAriane Sharif

11 Genetic Strategies Examining Kisspeptin Regulation of GnRH Neurons 259

Michael Candlish,Philipp WartenbergandUlrich Boehm

12 KNDy Hypothesis for Generation of GnRH Pulses: Evidence from Sheep and Goats 289

Robert L. Goodman,Satoshi Okhura,Hiroaki Okamura, Lique M. CoolenandMichael N. Lehman

13 Generation of the GnRH Surge and LH Surge by the Positive Feedback Effect of Estrogen 325

Iain Clarke

14 Influence of Stress on the GnRH Neuronal Network 357

Pasha GrachevandKevin T. O'Byrne

15 Metabolic Regulation of GnRH Neurons 383

Maggie C. EvansandGreg M. Anderson

16 Seasonal Control of the GnRH Neuronal Network as a Means of Uncovering Novel CentralMechanisms Governing Mammalian Reproduction 411

Sébastien Milesi,Paul KlosenandValerie Simonneaux

Part V GnRH in the Clinic

17 Human Genetics of GnRH Neuron Function 445

A. Kemal TopalogluandL. Damla Kotan

18 Modulators of GnRH Secretion and Therapeutic Applications 469

Claire L. Newton,Ross C. AndersonandRobert P. Millar

Index 499