Natural Products Analysis

Preface ix
Contributors xi
1. Natural Products Analysis: Instrumentation, Methods, andApplications 1
Vladimír Havlíèek and JaroslavSpí?ek
2. The Need for New Antifungal and Antimalarial Compounds9
Jaroslav Spí?ek and Arnold L. Demain
3. Emerging Instrumental Methods for Antimicrobial Resistanceand Virulence Testing 25
Plamen A. Demirev
4. Plant and Marine Sources: Biological Activity of NaturalProducts and Therapeutic Use 43
Amedeo Amedei and Elena Niccolai
5. Emerging Trends for Stimulating the Discovery of NaturalProducts 115
Navid Adnani, Gregory A. Ellis, Thomas P. Wyche, Tim S. Bugni,Jason C. Kwan, and Eric W. Schmidt
6. Advances and Challenges in Optical Molecular SpectroscopyIncluding Surface Plasmon Resonance-Based Methods for Bioanalysis163
Pavel Matìjka, Blanka Vlèková, LucieBednárová, and Petr Malon
7. Advanced Techniques for NMR Analysis of Complex BiologicalMixtures--From Simple NMR to Hyphenated Techniques 239
Helena Pelantová, Simona Bártová, and MarekKuzma
8. Advances in X-Ray Diffraction: Implications to thePharmaceutical Industry 285
Alexandr Jegorov and Michal HuSák
9. Laser Ablation Inductively Coupled Plasma Mass Spectrometryas a Tool in Biological Sciences 313
Michaela VaSinová Galiová, Jan HavliS, andViktor Kanicky
10. Imaging Mass Spectrometry, Metabolism, and New Views of theMicrobial World 349
B. Christopher Hoefler and Paul D. Straight
11. Structural Separations for Natural Product Characterizationby Ion Mobility-Mass Spectrometry: Fundamental Theory toEmerging Applications 397
Sarah M. Stow, Nichole M. Lareau, Kelly M. Hines, C. RuthMcNees, Cody R. Goodwin, Brian O. Bachmann, and John A.McLean
12. High-Resolution Tandem Mass Spectrometry for NonribosomalPeptide and Polyketide Analysis 433
Rebecca H. Wills, Manuela Tosin, and Peter B.O'Connor
13. Natural Product Drug Discovery and Analysis Using MassSpectrometry and Affinity-Based Technologies 475
Evelyn H. Wang and Kevin A. Schug
14. Glycosylated Ribosomally Synthesized Peptide Toxins:Discovery, Characterization, and Applications 507
Gillian E. Norris and Mark L. Patchett
15. Using Ultrahigh-Resolution Mass Spectrometry to Unravel theChemical Space of Complex Natural Product Mixtures 545
Constanze Müller, Mourad Harir, Norbert Hertkorn, BasemKanawati, Dimitrios Tziotis, and Philippe Schmitt-Kopplin
16. Functional Amyloid Fibrils: Lessons from Microbes 571
Sally L. Gras and Dennis Claessen
Index 601