This book deals with the mechanism of signal transduction in vertebrate and invertebrate photoreceptors. It contains contributions on the structure and function of rhodopsin or other G-coupled receptors, on the regulation of second messengers by enzyme cascade, the role of Ca2+ in light adaptation, control of ionic channels in photoreceptor cells.
Reihe
Sprache
Verlagsort
Verlagsgruppe
Illustrationen
34
34 s/w Abbildungen
XI, 318 p. 34 illus.
Dateigröße
ISBN-13
978-3-642-76482-0 (9783642764820)
DOI
10.1007/978-3-642-76482-0
Schweitzer Klassifikation
Hermann Kühn - In Memoriam.- Plenary Lecture.- The Eyes of Halobacteria.- I Rhodopsin - Structure and Function.- Mutagenesis Studies of Rhodopsin Phototransduction.- Structural Stability of Rhodopsin and Opsin Studied by Differential Scanning Calorimetry.- Molecular Analysis of Photoreceptor Protein Function.- Octopus Rhodopsin.- II Transducin and Phosphodiesterase.- The Activation of Transducin: Studies on its Mechanism and Modulation.- The Transitory Complexes Between Photoexcited Rhodopsin and Transducin. Biochemical and Spectroscopic Studies.- The Rate of GTP Hydrolysis by Transducin and the Termination of the cGMP Cascade in Retinal Rods.- The Molecular Biology of the Rod Photoreceptor cGMP Phosphodiesterase ?- and ?-Subunits.- III Deactivation Mechanisms.- The Phosphorylation of Rhodopsin.- Mechanisms of ?-Adrenergic Receptor Desensitization.- IV The cGMP-gated Channel.- Gating Kinetics of the cGMP-Activated Conductance of Retinal Cones.- Molecular Properties of the cGMP-gated Cation Channel of Rod Photoreceptor Cells as Probed with Monoclonal Antibodies.- Cyclic Nucleotide-gated Channels - A Family of Proteins Involved in Vertebrate Photoreception and Olfaction.- V Ca2+ Metabolism and Light Adaptation.- Interactions Between Calcium and cGMP in Dialyzed Detached Retinal Rod Outer Segments.- The Role of Cytoplasmic Calcium Concentration in Photoreceptor Light Adaptation.- Photoreceptor Guanylate Cyclase and Its Regulation by Calcium.- VI Transduction in Invertebrates.- Cyclic-GMP Phosphodiesterase in Photoreceptor Cells in Limulus Ventral Eye.- The Molecular Mechanism of Retinal Degeneration in the Retinal Degeneration B (rdgB) Mutant of Drosophila.- Glycosylation of Dipteran Opsins During Membrane Biogenesis.- Molecular Genetics of Visual Transduction inDrosophila.- Index of Contributors.
