This book features selected aspects of the molecular endocrinology of the testis with specific emphasis on signal transduction and gene regulation. Each chapter is written by internationally recognized authorities. Covering both basic research and clinical andrology, the book presents subjects as hormonal gene regulation and post-meiotic gene expression. Molecular endocrinology and pathophysiology of GnRH deficiency and the LH and FSH receptors are presented. Components of cyclic nucleotide-dependent signalling systems are discussed. Furthermore, regulation and pathophysiology of steroidogenesis and androgen action are presented, as well as tyrosine kinase-mediated signalling in germ cells and sperm. Finally, research in andrology and novel methods for in vitro fertilization are discussed.
Reihe
Sprache
Verlagsort
Verlagsgruppe
Illustrationen
37 s/w Abbildungen
XXI, 354 p. 37 illus.
Dateigröße
ISBN-13
978-3-662-03230-5 (9783662032305)
DOI
10.1007/978-3-662-03230-5
Schweitzer Klassifikation
1 The Roles of the Cell-Selective Nuclear Receptor SF-1 in Reproductive Function.- 2 Regulation of Steroid Hormone Production.- 3 A Role for cAMP-Response Element Motifs in Transcriptional Regulation of Postmeiotic Male Germ Cell-Specific Genes.- 4 Cyclic Nucleotide-Gated Channels in Sperm.- 5 CREM: A Transcriptional Master Switch Governing the cAMP Response in the Testis.- 6 Targeted Disruption of the Protein Kinase A System in Mice.- 7 Posttranscriptional Regulation of Postmeiotic Gene Expression.- 8 Isolation and Culture of Immature Rat Type A Spermatogonial Stem Cells.- 9 Androgen Receptor in Transcriptional Regulation.- 10 The 3?-Hydroxysteroid Dehydrogenase/Isomerase Gene Family: Lessons from Type II 3?-HSD Congenital Deficiency.- 11 The Src Family of Protein Tyrosine Kinases.- 12 Sperm-Zona Pellucida Interaction: A Model for Zona Receptor Kinase-Mediated Signaling.- 13 The Use of Spermatids for Human Conception.- 14 Evidence-Based Andrology: The Importance of Controlled Clinical Trials.- 15 Molecular Genetics and Neurobiology of Kallmann's Syndrome.- 16 The Polymorphisms of Gonadotropin Action: Molecular Basis and Clinical Implications.- Previous Volumes Published in this Series.
