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This book discusses the clinical management of adolescents with liver disease bridging the gap between pediatric and adult hepatology patient management. Expert views on liver disease in adolescence are discussed and specific differences for this patient subset are highlighted and examined in depth. The reader will gain the specific knowledge required on pathophysiology and treatment, but also about additional aspects such as psychological difficulties and cultural differences including use of social media.
Edited by two experts in the field and authored by international experts in the area using a multidisciplinary approach, this book is a helpfultool in managing these complex patients and will help minimise their complication rates and improve outcomes by the end of their transition periods.
Professor Nedim Hadzic is a Pediatric Hepatologist at King's College Hospital, London, which is arguably the world's busiest paediatric liver unit, since 1994. His main clinical research interests are biliary atresia, alpha-1 antitrypsin deficiency, primary immune deficiencies, liver-based metabolic conditions and liver transplantation. His publication record includes more than 200 articles and reviews in international journals and 25 textbook chapters. He has edited the world's first book on paediatric liver transplantation (Elsevier) published in 2020. He is a frequent invited speaker at conferences worldwide. His editorial activities include premier paediatric and hepatology journals. Since 2012, he is Professor of Paediatric Hepatology at King's College Medical School in London.
Dr Marianne Samyn has been part of the Paediatric Hepatology team at King's College Hospital since 2004. She was involved in the setup of the clinical service for young peoplewith liver disease aged 12-25 years in 2009 and has been the clinical lead since. The busy service provides a unique holistic multidisciplinary care model for young people during adolescence and transition to adult services. Aside from adolescent medicine including adherence and mental health, she has an interest in long-term outcome of paediatric liver diseases as well as paediatric liver transplantation and autoimmune liver disease. She is frequently invited on both national and international platforms to share her experience of working with young people with liver disease, amongst others. Dr Samyn has published in peer-reviewed journals and contributed to several textbooks. She is a Senior Clinical Lecturer at King's College Medical School in London.
Introduction .- The impact of liver disease on adolescent development .- a. Adolescent development .- b. Impact of liver disease on adolescent development .- i. Biological impact including growth and nutrition .- ii. Psycho-social impact .- Specific liver diseases .- a. Biliary atresia .- b. Alagille syndrome .- c. Alpha 1 antitrypsin deficiency .- d. Genetic cholestatic disorders .- e. Autoimmune hepatitis and sclerosing cholangitis .- f. Wilson disease .- g. Non-alcoholic fatty liver disease .- h. Portal hypertension .- i. Cystic fibrosis .- j. Sickle cell disease .- Liver transplantation in adolescence .- a. Listing for liver transplantation: criteria, timing and waitlist, Re-transplantation .- b. Long-term patient and graft outcome .- Challenges for adolescents and young adults with liver disease .- a. Adherence to treatment .- b. Mental health problems .- c. Health related quality of life .- d. Education and employment .- e. Alcohol and recreationaldrugs .- f. Fertility and pregnancy .- Provision of youth friendly liver services beyond transition .- a. Engaging young people: communication skills .- b. Development of self-management skills .- c. Peer support .- d. Models of care for adolescents and young adults including transition from paediatric to adult care .- What is it like to .. .- a. be young and have a liver disease? .- b. be a parent of a young person with liver disease .- c. look after a young person with liver disease .
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