The vast growth of knowledge in recent years concerning the functional role of serotonergic systems in central nervous system function prompted the organization of the symposium. The organiz ing committees felt at the onset that the field of serotonin research had grown so rapidly that it would be impossible to cover every aspect of it in individual symposia. Thus it was felt that certain areas of research had to be omitted due to time constraints, and we extend an apology to the researchers in areas not included in these proceedings. Rather it was hoped to provide a balance overview of the field, starting with the anatomy of serotonergic systems and proceeding to the level of the serotonergic receptors at the cell membrane, and then inside the neuron to discuss the regulation of serotonin bisynthesis and integration within indole mine systems. The functional aspects of serotonergic transmission focused on the emerging role of this amine in the processing of nociceptive information, singly or in tandem with other neurotran smitters or neuromodulators. A separate symposium dealt with a variety of animal models suitable for the analysis of the role of serotonin in behavior, and finally led to the evaluation of serotonin metabolism in the study of abnormal human behavior. The editors would like to dedicate these proceedings on /Serotonin - Current Aspects of Neurochemistry and Function/ to two pioneers in this field, Dr. Irving Page and Dr. Maurice Rapport.
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ISBN-13
978-1-4684-3860-4 (9781468438604)
DOI
10.1007/978-1-4684-3860-4
Schweitzer Klassifikation
Section I Neuroanatomy of Serotonergic and Related Systems.- Localization of Serotonin-Like Immunoreactivity in the Central Nervous System and Pituitary of the Rat, with Special References to the Innervation of the Hypothalamus.- Serotonin Binding Protein: Role in Transmitter Storage in Central and Peripheral Serotoneroic Neurons.- Radioautographic Investigation of Serotonin Cells.- Anatomical Evidence for GABA-5 HT Interaction in Serotonergic Neurons.- Evidence for the Coexistence of Serotonin and Substance P in Single Raphe Cells and Fiber Plexuses: Combined Immunocytochemistry and Autoradiography.- Section II Role of Serotonin in Processing of Nociceptive Information.- Effects of Peripherally and Centrally Administered Serotonin on Primate Spinothalamic Neurons.- The Role of Serotonin in Modulation of Nociceptive-Reflexes.- Role of the Raphe Nuclei in Stimulation Producing Analgesia.- Descending Control of Pain Transmission: Possible Serotonergic-Enkephalinerginc Interactions.- Section III The Regulation of Synthesis.- Synthesis and Quantitative Aspects of Dihydrobiopterin Control of Cerebral Serotonin Levels.- Influence of Plasma Trytophan on Brain 5-HT Synthesis and Serotonergic Activity.- Tryptophan Availability and the Control of 5-Hydroxytryptamine and Tryptamine Synthesis in Human CNS.- Regulatory Properties of Neuronal Tryptophan Hydroxylase.- Studies of the Oxygen Sensitivity of Tryptophan Hydroxylase.- Influence of Histamine on Serotonin Metabolism in Rat Brain.- Serotonin and Dopamine Synthesis in Phenylketonuria.- Section IV Serotonin Receptors.- Effect of Serotonin and Melatonin on the Electrophysiological Behaviour of the Plasma Membrane.- Identification of Serotonin-Binding Proteins Using a Photoaffinity Labeling Probe.- Serotonin-Receptors Coupled withan Adenylate Cyclase in the Rat Brain: Non-Identity with 3H-5-HT Binding Sites.- Brain Serotonin Receptors and Neuropsychiatrie Disorders.- Structure-Activity Relationships in the Actions of 1-Phenyl-Piperazines on Brain Serotonin Receptors.- Section V Regulation and Integration of Serotonergic Systems.- The Action of Serotonin in the Rat Hippocampus.- Uptake and Metabolism of Serotonin and Amino Acids in Thiamine Deficiency.- The Serotonin Connection: Some Evidence for a Specific Metabolic Organization.- Role of Serotonin in the Hypothalamic Regulation of Pituitary Function.- Evidence for Neuronal Feedback Regulation of Serotonin Formation in Brain.- Section VI Developmental Aspects of Serotonergic Systems.- Neurohumor Substances as Neural Growth Factors.- Roles for Serotonin in Neuroembryogenesis.- Developmental-Regulatory Aspects of Brain Tryptophan Hydroxylase.- Serotonin in Development of Cyclic Reproductive Function.- Section VII Serotonin and Behavior-Animal Models.- The Interaction of Indole Derivatives with the Serotonin Receptor and Non-Dopaminergic Cicrling Behavior.- Some Behavioural Interactions between 5-Hydroxytryptamine and Dopamine.- Serotonergic-Dopaminergic Interactions: Implications for Hyperkinetic Disorders.- Serotonin Metabolism of Animal Model of Depression.- Hypersensitive Serotonergic Receptors: A New Hypothesis for one Subgroup of Unipolar Depression Derived from an Animal Model.- An Animal Behavior Model for Decreased Central Serotonergic Function.- Studies on the Role of Central 5-HT Neurons in Avoidance Learning: A Behavioral and Biochemical Analysis.- Section VIII Serotonin and Behavior Psychiatry.- On the Clinical Significance of Serotonin and 5-HIAA in Body Fluids.- Serotonin Metabolite Concentrations in Cerebrospinal Fluid from Schizophrenic Patients - Relationships to Family History.- Tryptophan in the Treatment of Depression.- Studies of CSF 5-HIAA in Depression and Suicidal Behaviour.- Serotonin and Dopamine Disturbances in Patients with Unipolar Depression and Parkinsonism.- Abstracts.- ccelerated Turn-Over of Spinal 5-HT by Electrical Stimulation of the Posterior Raphe Nuclei in the Rat.- Actions of Benzodiazepine Drugs on Cerebral 5-Hydroxytryptamine Mechanism in the Mouse.- A Serotoninergic Happening in the Locus Coeruleus: A Radioautographic and Biochemical Demonstration.- Central Interactions of Kynurenine with Serotonin: Direct or Indirect?.- ?-Chloroamphetamine and ?-Methyltryptamine-Correlation of Behavioural Response with 5TH Release.- Correlations between Rat Brain 5-Hydroxytryptamine Metabolism and the Analgesic Response to Footshock in Non-Drug Treated Rats.- Developmental Changes in the Turnover of Mao A in the Rat Brain.- Differential Radioautography of 3H-5 HTP or 3H-DOPA Concentrating Cells in the Brain Stem of Insomniac Cats.- Evaluation of Central Serotonergic and Antiserotonergic Activities.- Hyperactivity in Rats Treated with Monoamine Oxidase Inhibitors and the Specific 5-HT Reuptake Blocker LM-5008.- Interactions between Serotonergic and Dopaminergic Systems in Rat Brain Demonstrated by Small Unilateral Lesions of the Raphe Nuclei.- In Vivo Uptake and Retrograde Axonal Flow of 3H-5 HT by Central Serotoninergic Systems.- Involvement of 5-Hydroxytryptamine in Caudate Dopamine Release Following Tail-Pinch: Studies with Linear Sweep Voltammetry in Vivo.- Latency of Sleep Inducing Effects of 5HTP in PCPA Pretreated Cats.- Possible Dopaminergic Control of newly Synthetized 3H-Serotonin Released in Vivo from the Caudate Nucleus and the Substantia Nigra of the Cat.- Release of3H-5HT from Slices of Rat Substantia Nigra and Corpus Striatum in Vitro Mediated by Dopamine Receptors.- Serotonin Specific Adenylate Cyclase in Synaptosomal Membranes.- Substances Related to 5-Hydroxytryptamine in Plasma, Lumbar CSF, Venticular CSF and Frontal Cortex of Psychiatric Patients with and without Tryptophan Infusion.- Tryptophan Metabolism and 5HT in Schizophrenia.
