This volume looks at the latest techniques used to perform comparative structure analyses, and predict and evaluate protein-ligand interactions. The chapters in this book cover tools and servers such as LiteMol; Bio3D-Web; DALI; CATH; HoTMuSiC, a contact-base protein structure analysis tool known as CAD-Score; PyDockSaxs and HADDOCK; CombDock and DockStar; the BioMagResBank database; as well as BME and CoNSEnsX+. Written in the highly successful
Methods in Molecular Biology
series format, chapters include introductions to their respective topics, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and comprehensive,
Structural Bioinformatics: Methods and Protocols
is a practical guide for researchers to learn more about the aforementioned tools to further enhance their studies in the growing field of structural bioinformatics.
Chapter 13 isavailable open access under a CC-BY 4.0 license via link.springer.com.
Reihe
Sprache
Verlagsort
Verlagsgruppe
Illustrationen
10
76 farbige Abbildungen, 10 s/w Abbildungen
XII, 256 p. 86 illus., 76 illus. in color.
Dateigröße
ISBN-13
978-1-0716-0270-6 (9781071602706)
DOI
10.1007/978-1-0716-0270-6
Schweitzer Klassifikation
Visualization and Analysis of Protein Structures with LiteMol Suite.- Comparative Protein Structure Analysis with Bio3D-Web.- Using DALI for Protein Structure Comparison.- Assessing Protein Function through Structural Similarities with CATH.- Protein Thermal Stability Engineering using HoTMuSiC.- Contact Area-Based Structural Analysis of Proteins and their Complexes using CAD-Score.- A Comprehensive Computational Platform to Guide Drug Development using Graph-Based Signature Methods.- Systematic Exploration of Binding Modes of Ligands on Drug Targets.- Using MemBlob to Analyze Transmembrane Regions Based on Cryo-EM Maps.- Structural Characterization of Protein-Protein Interactions with pyDockSAXS.- Protein-Protein Modeling using Cryo-EM Restraints.- Modeling of Multimolecular Complexes.- Biological Assembly Comparison with VAST+.- BioMagResBank (BMRB) as a Resource for Structural Biology.- Integrating MolecularSimulation and Experimental Data: A Bayesian/Maximum Entropy Reweighting Approach.- Evaluation and Selection of Dynamic Protein Structural Ensembles with CoNSEnsX+.
