List of Abbreviations

3-CR three-component reaction 4CC four-component condensation Ac acetyl ACM alkyne cross metathesis ADMAC acyclic diene metathesis macrocyclization ADMET acyclic diene metathesis ADIMET acyclic diyne metathesis Agl allyl glycine AIBN azobisisobutyronitrile Alloc allyl carbamate API active pharmaceutical ingredient ARCM asymmetric ring-closing metathesis ATRA atom transfer radical addition AVM arylenevinylene macrocycles B/C/P build/couple/pair BBN borabicyclo[3.3.1]nonane BHT 2,6-di-tert-butyl-4-methylphenol BINAP 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl BINOL 1,1´-bi(2-naphthol) Bn benzyl Boc tert-butyoxycarbonyl BODIPY boron-dipyrromethene BOM benzyloxymethyl BOP benzotriazol-1-yloxytris(dimethylamino)-phosphonium hexafluorophosphate BPS, TBDPS tert-butyldiphenylsilyl BRSM, brsm based on recovered starting material Bs brosyl, p-bromobenzenesulfonyl BTIB bis(trifluoroacetoxy)iodobenzene Bz benzoyl CAN ceric ammonium nitrate CBS Corey-Bakshi-Shibata Cbz benzyloxycarbonyl CD circular dichroism CDI 1,1'-carbonyldiimidazole CDT cyclododecatriene CLPCS cyclolinear polycarbosilanes CM cross-metathesis CME carboxymethyl migrastatin ether CNS central nervous system COD 1,5-cyclooctadiene COGs cost-of-goods Cp* pentamethylcyclopentadienyl CPA chiral phosphoric acid CSA camphorsulfonic acid CSI chlorosulfonyl isocyanate Cy cyclohexyl DA Diels-Alder DABCO 1,4-diazabicyclo[2.2.2]octane Das diaminosuberic acid dba dibenzylideneacetone dbcot dibenzo[a,e]cyclooctatetraene DBU 1,8-diazabicyclo[5.4.0]undec-7-ene DCC dicyclohexylcarbodiimide DCE 1,2-dichloroethane DCM dichloromethane DDA dodecenoate DDE dimethyl dodecanedioate DDQ 2,3-dichloro-5,6-dicyano-1,4-benzoquinone DEAD diethyl azodicarboxylate DFT density functional theory Dha dehydroalanine DIAD diisopropyl acetylenedicarboxylate DIBAL-H diisobutylaluminium hydride DIEA, DIPEA N,N-diisopropylethylamine; Hünig's base DMAD dimethyl acetylenedicarboxylate DMAP 4-dimethylaminopyridine DMB 2,4-dimethoxybenzyl DMBM 3,4-dimethoxybenzyloxymethyl DMDA dimethyldiacetylene DME 1,2-dimethoxyethane DMF dimethylformamide DMP Dess-Martin periodinane DMPU N,N´-dimethylpropylene urea DMSO dimethylsulfoxide DOS diversity-oriented synthesis DOSP N-(dodecylbenzenesulfonyl)prolinate) dppp 1,3-bis(diphenylphosphino)propane DSRCM diastereoselective ring-closing metathesis DTBP 2,6-di-tert-butylphenol DTS diverted total synthesis EDA ethyl diazoacetate EDC, EDCI 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide EDG electron donor group ELT end-of-life tire EM effective molarity ERCM enantioselective ring-closing metathesis EROCM enantioselective ring-opening/cross-metathesis ERORCM enantioselective ring-opening/ring-closing metathesis Ery erythromycin EWB electron withdrawing group FAME fatty acid methyl esters FGP functional group pairing Fmoc fluorenylmethyloxycarbonyl FRET fluorescence resonance energy transfer F-SPE fluorous-solid-phase extraction FTO freedom to operate GFP green fluorescent protein GHRH growth-hormone-releasing hormone GSK GlaxoSmithKline HBS hydrogen-bond surrogate HCV hepatitis C virus HDAC histone deacetylase HFIP hexafluoroisopropanol HH head-to-head HMPA hexamethylphosphoramide HMSBO hydrogenated metathesized soybean oil HNBR hydrogenated nitrile butadiene rubber HO-DEAD hydrogenated oligomeric azodicarboxylate HPK hetero-Pauson-Khand HPLC high-performance liquid chromatography HRMS high-resolution mass spectrometry HT head-to-tail HTS high-throughput screening HWE Horner-Wadsworth-Emmons IMDA intramolecular Diels-Alder IMes 1,3-dimesityl-imidazolidin-2-ylidene iNOS inducible nitric oxide synthase IP intellectual property Ipc isopinocampheyl KHMDS potassium bis(trimethylsilyl)amide LACDAC Lewis acid catalyzed diene-aldehyde cyclocondensation LCMS liquid chromatography mass-spectrometry LDA lithium diisopropylamide LiHMDS lithium bis(trimethylsilyl)amide LUMO lowest unoccupied molecular orbital M&M metathesis and metallotropy MALDI-MS matrix-assisted laser desorption/ionization mass spectrometry MAP monoaryloxide pyrrolide mCPBA m-chloroperbenzoic acid ME migrastatin ether MEM 2-methoxyethoxymethyl Mes mesityl MIDA N-methyliminodiacetic acid MM molecular...