1. Introduction2. DNA Methylation & Hydroxymethylation in Cancer3. Writers, Readers, and Erasers of Epigenetic Marks4. MicroRNAs and Cancer5. Long Noncoding RNAs (lncRNAs) and Cancer6. Ribosomal RNA Methylation and Cancer7. Mining the Epigenetic Landscape: Surface Mining or Deep Underground8. Development of Epigenetic Targeted Therapies in Hematological Malignancies: From Serendipity to Synthetic Lethality9. Epigenetic Therapy in Lung Cancer and Mesothelioma10. Breast Cancer Epigenetics11. Therapeutic Applications of the Prostate Cancer Epigenome12. Liver Cancer (Hepatocellular Carcinoma)13. Neuroblastoma14. The Epigenetics of Medulloblastoma15. Clinical Significance of Epigenetic Alterations in Glioblastoma16. Esophageal Cancer17. Nasopharyngeal Cancer18. Nutritional Epigenetic Inhibitors in the Field of Cancer: New Avenues for Chemopreventive Approaches19. Emerging Epigenetic Therapies - Lysine Methyltransferase/PRC Complex Inhibitors20. Inhibitors of Jumonji C Domain Histone Demethylases21. Emerging Epigenetic Therapies - Lysine Acetyltransferase Inhibitors22. Emerging Epigenetic Therapies - Bromodomain Ligands23. Clinical Trials24. Genetic Intratumor Heterogeneity25. Epigenetics Underpinning DNA Damage repair26. Epigenetics of Cisplatin Resistance27. Therapeutically Targeting Epigenetic Regulation of Cancer Stem Cells28. Personalized Therapy - Chemosensitivity Testing29. Personalized Therapy - Epigenetic Profiling as Predictors of Prognosis and Response
List of Contributors
Bryce K. Allen, Center for Therapeutic Innovation, The Miami Project to Cure Paralysis, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA
Donat Alpar, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
Viren Amin, Epigenome Center, Baylor College of Medicine, Houston, Texas, USA
Fazila Asmar, Department of Hematology, Rigshospitalet, Copenhagen, Denmark
Nagi G. Ayad, Center for Therapeutic Innovation, The Miami Project to Cure Paralysis, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA
Anne-Marie Baird
Genome Stability Laboratory, Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, Queensland, Australia
Thoracic Oncology Research Group, Institute of Molecular Medicine, St. James's Hospital, Dublin, Ireland
Louise J. Barber, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
Becky A.S. Bibby, Cancer Biology and Therapeutics Lab, School of Biological, Biomedical and Environmental Sciences, University of Hull, Yorkshire, UK
Emma Bolderson, Genome Stability Laboratory, Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, Queensland, Australia
Philippe Bouvet, Laboratoire Joliot-Curie, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, France
Frédéric Catez
Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Lyon, France
Université de Lyon, Lyon, France
Leandro Cerchietti, Hematology and Oncology Division, Medicine Department, Weill Cornell Medical College of Cornell University, New York, NY, USA
Snehajyoti Chatterjee
Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka, India
Laboratoire de Neurosciences Cognitives et Adaptatives, Université de Strasbourg-CNRS, GDR CNRS, Strasbourg, France
Taiping Chen
Department of Molecular Carcinogenesis and the Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Smithville, Texas, USA
The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas, USA
Andreas I. Constantinou, Laboratory of Cancer Biology and Chemoprevention, Department of Biological Sciences, School of Pure and Applied Sciences, University of Cyprus, Nicosia, Cyprus
Stuart J. Conway, Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, UK
Dashyant Dhanak, Janssen Research & Development, Spring House, PA, USA
Jean-Jacques Diaz
Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Lyon, France
Université de Lyon, Lyon, France
Marc Diederich, College of Pharmacy, Seoul National University, Gwanak-gu, Seoul, Korea
Xinmin Fan, Department of Pathology, The Shenzhen University School of Medicine, Shenzhen, Guangdong, People's Republic of China
Brendan Ffrench, Department of Pathology, Coombe Women's and Infant's University Hospital, Dublin, Ireland
Michael F. Gallagher, Department of Histopathology, University of Dublin, Trinity College, Trinity Centre, St James Hospital, Dublin, Ireland
Marco Gerlinger, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
Steven D. Gore, Department of Internal Medicine (Hematology), Yale Cancer Center, New Haven, CT, USA
Steven G. Gray
HOPE Directorate, St. James's Hospital, Dublin, Ireland
Thoracic Oncology Research Group, Institute of Molecular Medicine, St. James's Hospital, Dublin, Ireland
Kirsten Grønbæk, Department of Hematology, Rigshospitalet, Copenhagen, Denmark
David S. Hewings, Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, UK
Holger Heyn, Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, Barcelona, Catalonia, Spain
Zhe Jin
Department of Pathology, The Shenzhen University School of Medicine, Shenzhen, Guangdong, People's Republic of China
Shenzhen Key Laboratory of Micromolecule Innovatal Drugs, The Shenzhen University School of Medicine, Shenzhen, Guangdong, People's Republic of China
Shenzhen Key Laboratory of Translational Medicine of Tumor, The Shenzhen University School of Medicine, Shenzhen, Guangdong, People's Republic of China
Stephanie Kaypee, Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka, India
Yutaka Kondo, Department of Epigenomics, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya, Japan
Tapas K. Kundu, Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka, India
Florian Laforêts
Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Lyon, France
Université de Lyon, Lyon, France
Matthew W. Lawless, Experimental Medicine, UCD School of Medicine and Medical Science, Mater Misericordiae University Hospital, Catherine McAuley Centre, Dublin, Ireland
Stephen G. Maher, Cancer Biology and Therapeutics Lab, School of Biological, Biomedical and Environmental Sciences, University of Hull, Yorkshire, UK
Somnath Mandal
Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka, India
Department of Biochemistry, Faculty of Agriculture, Uttar Banga Krishi Viswavidyalaya, Pundibari, Cooch-Behar, West Bengal, India
Virginie Marcel
Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Lyon, France
Université de Lyon, Lyon, France
Aleksandar Milosavljevic, Epigenome Center, Baylor College of Medicine, Houston, Texas, USA
Hannah L. Moody
Cancer Biology and Therapeutics Lab, School of Biological, Biomedical and Environmental Sciences, University of Hull, Yorkshire, UK
Hull York Medical School, Yorkshire, UK
Atsushi Natsume, Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
Thomas B. Nicholson, Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, MA, USA
Kenneth J. O'Byrne
Genome Stability Laboratory, Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, Queensland, Australia
Thoracic Oncology Research Group, Institute of Molecular Medicine, St. James's Hospital, Dublin, Ireland
Shane O'Grady, Experimental Medicine, UCD School of Medicine and Medical Science, Mater Misericordiae University Hospital, Catherine McAuley Centre, Dublin, Ireland
John J. O'Leary, Department of Pathology, Coombe Women's and Infant's University Hospital, Dublin, Ireland
Fumiharu...
