Protein Surface Recognition

A new perspective on the design of molecular therapeutics isemerging. This new strategy emphasizes the rational complementationof functionality along extended patches of a protein surface withthe aim of inhibiting protein/protein interactions. The successfuldevelopment of compounds able to inhibit these interactions offersa unique chance to selectively intervene in a large number of keycellular processes related to human disease.
Protein Surface Recognition presents a detailed treatmentof this strategy, with topics including:
* an extended survey of protein-protein interactions that are keyplayers in human disease and biology and the potential fortherapeutics derived from this new perspective
* the fundamental physical issues that surround protein-proteininteractions that must be considered when designing ligands forprotein surfaces
* examples of protein surface-small molecule interactions,including treatments of protein-natural product interactions,protein-interface peptides, and rational approaches to proteinsurface recognition from model to biological systems
* a survey of techniques that will be integral to the discoveryof new small molecule protein surface binders, from high throughputsynthesis and screening techniques to in silico and invitro methods for the discovery of novel protein ligands.
Protein Surface Recognition provides an intellectual"tool-kit" for investigators in medicinal andbioorganic chemistry looking to exploit this emerging paradigm indrug discovery.