The Italian Group for the Study of Liver Cirrhosis began its activity in 1980 on the basis of recognition and financial support from the Italian Ministry of the University, Scientific Research and Technology, having been chosen from several other scientific programs. The group is now called the National Group for the Study of Liver Cirrhosis and Viral Hepatitis and includes more than 40 centers throughout the nation under the auspices of the universities. The primary Imtlatlve of the group, to combine experimental and clinical approaches in the study of liver pathophysiology, remains unchanged. Annual meetings in January provide the possibility of comparing experimental and clinical results in the spirit of mutual comprehension and criticism. After 15 years and 6 volumes (published biannually), the actual improvement of Italian research in liver pathophysiology is evident. In fact, in order to let other researchers know what has been achieved we chose to publish the 7th volume, in spite of the economic difficulties at hand. We have gathered specific experiences of all the centers included in the national program. Each group was required to present an update in its own field of research, rather than specific or recently obtained results, which could have been reported only in relationship with other data already published by others. Like the 6th edition in our series, this volume affirms the specific competence of all the participants and summarizes the most important updates in liver pathophysiology.
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Dateigröße
ISBN-13
978-94-009-0357-9 (9789400903579)
DOI
10.1007/978-94-009-0357-9
Schweitzer Klassifikation
Section 1. Pathogenetic Mechanisms of Liver Injury.- 1 4-Hydroxy alkenals, products of lipid peroxidation, as signals for biochemical functions of normal cells.- 2 Oxidative stress and protein kinase C activity modulation.- 3 Oxidative damage in chronic liver disease.- 4 Chronic ethanol consumption impairs dolichol levels and glycosylation processes in rat liver microsomes and Golgi apparatus.- 5 Compartmentation and redox state of thiols and proteins during acute ethanol intoxication in rats.- 6 Possible role of ethanol-derived free radicals in the pathogenesis of alcohol-induced liver damage.- 7 Hepatic iron overload induced by Phenylhydrazine: release of iron in a free form and DNA damage.- 8 The effects of development of the MDR 1 phenotype on cell susceptibility to undergoing lipid peroxidation and ionizing radiation.- 9 Molecular and cellular aspects of iron-mediated liver toxicity.- 10 The cellular and molecular basis of liver fibrogenesis.- 11 Proliferation of hepatic stellate cells and lipid peroxidation: changes due to polyphenols.- 12 Reoxygenation injury in isolated rat hepatocytes.- 13 Oxidative stress and cell damage following orthotopic liver transplantation.- 14 The genomic response of liver cells to post-ischemic reperfusion and oxidative stress.- Section 2. Pathophysiology of Bile Secretion.- 15 Cytotoxic and protective effects of bile salts in vitro.- 16 Lamellar bodies in human gallbladder bile.- 17 Hepatocyte lipid-metabolic interplays and the cholesterol secretion process to bile: insights from rat studies.- Section 3 Insights in Hepatic Carcinogenesis.- 18 Lipid peroxidation and hepatocarcinogenesis: ?-glutamyl transpeptidase- dependent oxidant stress in hepatic preneoplastic lesions and HEPG2 hepatoma cells.- 19 Antioxidant system inhepatocellular carcinoma.- 20 Loss of heterozygosity of the long arm of chromosome 16 in hepatocellular carcinoma on liver cirrhosis.- 21 Potential molecular mechanisms of viral liver carcinogenesis.- 22 Prevalence of wild-type and variant transcripts of liver estrogen receptors in chronic liver disease.- Section 4. Pathogenetic Aspects of Hepatitis C Virus (HCV) Infection.- 23 Molecular biology of HCV: implications in epidemiology and diagnosis of infection.- 24 Cell-mediated immune response in hepatitis C virus (HCV) infection: are different strategies adopted by HCV and hepatitis B virus to persist?.- 25 The epidemiological and clinical aspects of hepatitis C in Italy.- 26 Diagnostic evaluation of patients with chronic HCV infection.- 27 Correlation between hepatitis C virus RNA levels in serum, liver and peripheral blood mononuclear cells and severity of liver disease in chronic hepatitis C patients.- 28 Hepatitis C virus lymphotropism and possible pathogenetic implications.- 29 HCV-induced cryoglobulinemic vasculitis: pathogenesis and therapeutic implications.- Section 5. Clinical Aspects of Chronic Liver Disease.- 30 Cirrhosis associated congestive gastropathy. Physiopathological aspects.- 31 Treatment of ascites in cirrhosis.- 32 Spectral EEG monitoring of hepatic encephalopathy.- 33 Interaction between non steroidal anti inflammatory drugs and interferon-? system: mechanisms and basis for the clinical use in the treatment of chronic viral hepatitis.- 34 Pharmacological treatment of primary biliary cirrhosis.
