The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease

Part 1. Hypothalamic-pituitary-adrenal axis regulation of the body, brain, and inflammation.- 1. Glucocorticoid regulation of body composition and metabolism.- 2. Glucocorticoid regulation of neurocognitive and neuropsychiatric function.- 3. Glucocorticoids: Inflammation and Immunity.- Part 2. Cushing's Syndrome.- 4. Pathogenesis, diagnosis and localization of Cushing's: Molecular pathogenesis of primary adrenal Cushing's syndrome .- . 5. Pathogenesis, diagnosis and localization of Cushing's.- 5. Pathogenesis, diagnosis and localization of Cushing's: Pathogenesis and treatment of aggressive corticotroph pituitary tumors - Yang Shen and Anthony P Heaney.- 6. Pathogenesis, diagnosis and localization of Cushing's: Neoplastic/Pathologic and Non-neoplastic/Physiologic Hypercortisolism: Cushing verses Pseudo-Cushing Syndromes.- 7. Pathogenesis, diagnosis and localization of Cushing's: Imaging strategies for localization of ACTH - secreting tumors.- 8. Recent Advances in the medical andsurgical treatment of Cushing's: Surgical Treatment of Cushing's disease.- 9. Recent Advances in the medical and surgical treatment of Cushing's: Medical therapies in Cushing's syndrome.- 10. New themes in Cushing's definitions and outcomes: Mild adrenal cortisol excess - 11. New themes in Cushing's definitions and outcomes: Long term effects of prior Cushing's syndrome .- 12. New themes in Cushing's definitions and outcomes: Cushing's disease: refining the definition of remission and recurrence.- Part 3. Beyond Cushing's: Glucocorticoid sensitivity, regulation and the metabolic syndrome.- 13. Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis through a Mutated Glucocorticoid Receptor.- 14. Cortisol metabolism as a regulator of the tissue-specific glucocorticoid action.- 15. Obesity and metabolic syndrome: a phenotype of mild long-term hypercortisolism.