The Vasculome

PART I. THE ARCHITECTURAL DESIGN OF THE VASCULOME: BASIS FOR SYSTEM-WIDE FUNCTIONAL UNITY AND LOCAL DIVERSITYSECTION 1. The Endothelium: Key Unifying Principle of the Vasculome. Basis for Systemic Unity and for Engineering of Local Specialization 1. Developmental of, and environmental impact on, endothelial cell diversity2. Endothelial cell heterogeneity in health and disease - new insights from single cell studies SECTION 2. Vasculome's Key Building Blocks - Beyond the Endothelium3. The Remarkable Diversity of Vascular Smooth Muscle in Development and Disease: A paradigm for mesenchymal cell types4. SMC contractile diversity 5. Resident vascular immune cells in health and atherosclerotic disease6. Perivascular adipose tissue (physiology, pathology)7. Major vascular ECM components, differential distribution supporting structure and functions of the Vasculome SECTION 3. Putting it all Together: Integration across Body Scales and within Tissues 8. Out to the Tissues: The Arterial Side (Arteries, Arterioles - Development, Structure, Functions, Pathologies)9. Capillary diversity: endothelial cell specializations to meet tissue metabolic needs10. The neurovascular unit and blood-CNS barriers in health and disease11. Lymphatic biology and medicine PART II. INVESTIGATING THE VASCULOME: CONTEXT-DRIVEN METHODS, USES AND LIMITATIONSSECTION 1. Experimental and Computational Studies of the Vasculome12. The Flow-dependent Endotheliome: Hemodynamic Forces, Genetic Programs, and Functional Phenotypes13. Intravital photoacoustic microscopy of microvascular function and oxygen metabolism' 14. Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases15. Simulation of blood flow and oxygen transport in vascular networks16. Clinical Investigations of vascular function SECTION 2. Realizing the Promise of New High Content Technologies17. Angiodiversity - A tale retold by comparative transcriptomics18. Using Pattern Recognition and Discriminant Analysis of Functional Perfusion Data to Create "Angioprints for Normal and Perturbed Angiogenic Microvascular Networks 19. Artificial Intelligence (AI) for the Vasculome PART III. VASCULOME DYNAMICS: IN HEALTH AND IN SICKNESS SECTION 1. Cooperating during Development and Organogenesis to Create Vasculome Diversity20. Vascular Development and Organogenesis: Depots of Diversity among Conduits of Connectivity Define the Vasculome21. Normal Vascular Identity (arteries, veins, lymphatics) and malformations22. Sprouting Angiogenesis in Vascular and Lymphatic development SECTION 2. Physiological and Pathological Remodeling of the Vasculome23. Enablers and drivers of vascular remodeling 24. Extracellular Matrix Dynamics and Contribution to Vascular Pathologies25. Lymphatic vasculature anomalies and dysfunction PART IV. THE VASCULOME AS PERPETRATOR AND VICTIM IN LOCAL AND SYSTEMIC DISEASES26. Endothelial dysfunction: basis for many local and systemic conditions27. The vascular phenotype in hypertension28. Functional roles of lymphatics in health and disease29. Extracellular Matrix Genetics of Thoracic and Abdominal Aortic Diseases30. Peripheral arterial disease (pathophysiology, presentation, prevention/management)31. Venous Diseases Including Thromboembolic Phenomena PART V. THE VASCULOME IN DIAGNOSIS, PREVENTION, AND TREATMENT OF OTHER DISEASES 32. Targeting vascular zip codes: from combinatorial selection to drug prototypes33. Angiosome concept for vascular interventions34. RNA therapies for cardiovascular disease35. The Brain Vasculome: An Integrative Model for CNS Function and Disease PART VI. Looking Forward Toward "Precision Health" for the Vasculome36. Defining and Optimizing Vascular health37. The Vasculome provides a Body-wide Cellular Positioning System and Functional Barometer. The "Vasculature as Common Coordinate Frame (CCF) Concept