Microbial Life History

Name: Microbial Life History | The Fundamental Forces of Biological Design
Brand: Princeton University Press
Price: 46.99 EUR
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The Fundamental Forces of Biological Design

Steven A. Frank(Autor*in)

Princeton University Press

1. Auflage

Erschienen am 16. August 2022

400 Seiten

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978-0-691-23118-1 (ISBN)

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Inhalt

Cover
Contents
Preface
1. Microbial Design
How to Read
Theoretical Background
The Design of Metabolism
Part 1. Theoretical Background
2. Forces of Design
What Is Fitness?
The Difficulty of Measuring Fitness
3. Comparison and Causality
Comparative Predictions
Evolutionary Response versus Organismal Response
Fundamental Forces and Partial Causes
Causal Inference
Structure and Notation of Comparative Predictions
Recap and Goal
4. Brief Examples
Metabolism and Growth Rate
Support by Empirical Test
Patch Lifespan and Microbial Cancer
Heterogeneity in Public Goods
Stage-Dependent Growth
Summary
5. Theory: Forces
Tragedy of the Commons
Similarity Selection and Kin Selection
Tradeoffs and Marginal Values
Repression of Competition
Heterogeneity in Vigor and Public Goods
Demography and Reproductive Value
Stage-Dependent Traits in Life Cycle
The Three Measures of Value
Scaling of Time and Space
Variable Environments
6. Theory: Traits
Nature of Traits
Modification of Traits
Origin of Traits
7. Theory: Control
Error-Correcting Feedback and Robustness
Principles of Control
Error Correction and Signal Amplification
Robustness to Process Uncertainty
Responsiveness versus Homeostasis
Sensors
Control Tradeoffs
8. Studying Biological Design
Part 2. The Design of Metabolism
9. Microbial Metabolism
10. Growth Rate
Comparative Hypotheses in the Study of Design
Testing Comparative Predictions
Comparative Predictions about Growth Rate
Comparative Predictions about Tradeoffs
11. Thermodynamics: Biochemical Flux
Entropy Production
Force and Resistance Determine Flux
Mechanisms of Metabolic Flux Control
12. Flux Modulation: Driving Force
Near-Equilibrium Glycolysis
Overflow Metabolism: Mechanisms
Overflow Metabolism: Design Puzzles
Evolutionary Timescale
Alternative Glycolytic Pathways
13. Flux Modulation: Resistance
Resistance Impedes Flux
Mechanisms to Alter Resistance and Flux
Genetic Drift
Challenges in Control Design
Problems of Flux Modulation
Limitations and Prospects
14. Variant Pathways
Glycolytic Yield
Final Electron Acceptors
Weak Redox Gradients
Electron Flow between Cells
Alternative Carbon Sources
Hierarchical Usage of Complex Carbohydrates
Puzzles of Design
15. Tradeoffs
Biophysical Constraints and Cellular Allocation
Exploration versus Exploitation versus Regulation
Thermodynamics and Biochemical Flux
Fitness Components and Life History
Warfare versus Productive Traits
Cooperative Traits
Timescale Tradeoffs
Bet-Hedging Tradeoffs
Control Tradeoffs
Summary
16. Predictions: Overflow Metabolism
Comparative Predictions and Partial Causes
Background
Proteome Limitation
Membrane Space Limitation
Response to Environmental Challenge
Summary
17. Predictions: Diauxie, Electrons, Storage
Switching between Food Sources
Distributed Electron Flux
Storage When Resources Fluctuate
Challenges in the Study of Design
18. Design Revisited
References
Index

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