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This book serves as a reference and comprehensive guide for PET/MR neuroimaging. The field of PET/MR is rapidly evolving, however, there is no standard resource summarizing the vast information and its potential applications. This book will guide neurological molecular imaging applications in both clinical practice and the research setting.
Experts from multiple disciplines, including radiologists, researchers, and physicists, have collaborated to bring their knowledge and expertise together. Sections begin by covering general considerations, including public health and economic implications, the physics of PET/MR systems, an overview of hot lab and cyclotron, and radiotracers used in neurologic PET/MRI. There is then coverage of each major disease/systemic category, including dementia and neurodegenerative disease, epilepsy localization, brain tumors, inflammatory and infectious CNS disorders, head and neck imaging, as well as vascular hybrid imaging. Together, we have created a thorough, concise and up-to-date textbook in a unique, user-friendly format. This is an ideal guide for neuroradiologists, nuclear medicine specialists, medical physicists, clinical trainees and researchers.
Ana M. Franceschi, M.D., Ph.D.
Associate Professor of Radiology
Division of Neuroradiology
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
Dinko Franceschi, M.D.
Division Chief of Nuclear Medicine and PET Imaging
Renaissance School of Medicine at Stony Brook University
SECTION I: Introdcution to PET/MR.- Introduction to PET/MR.- SECTION II: Public Health and Economic Implications.- Utility of PET/MRI in Private Practice.- SECTION III: Physics of PET/MR Systems.- Physics of PET/MR Systems.- SECTION IV: Overview of Hot Lab and Cyclotron.- Overview of Hot Lab and Cyclotron.- SECTION V: Radiotracers in Neurologic PET/MRI.- FDG Metabolic Imaging.- Amyloid Dementia Imaging.- TAU Dementia Imaging.- Amino Acid Tumor Imaging.- FDOPA Dopaminergic Imaging.- DASB Serotonin Receptor Imaging.- FEPPA Microglial Activation Imaging.- [150]-H2O/CO2 Perfusion Imaging.- Fluciclovine (Axumin) glioma imaging.- Ga68 Dotatate neuroendocrine imaging.- Radiotracers in development.- SECTION VI: Dementia and Neurodegenerative Disease.- Alzheimer's disease.- MCI and dementia therapeutics.- Posterior cortical atrophy.- Dementia with Lewy Body.- Behavioral variant FTD (Pick's disease).- Semantic dementia.- Logopenic PPA.- Agrammatic PPA.- Progressive supranuclear palsy.- Multisystem atrophy.- Corticobasal degeneration.- Creutzfeld-Jacob disease.- Normal pressure hydrocephalus.- Crossed cerebellar diaschisis.- SECTION VII: Epilepsy Localization.- Seizure Focus Localization.- Developmental.- Acquired.- SECTION VIII: Brain Tumors.- Diagnosis.- Primary Brain Neoplasms.- Metastatic Disease.- Treatment Planning.- Treatment Response.- SECTION IX: Inflammatory and Infectious CNS Disorders.- Meningitis.- Encephalitis.- CNS Inflammatory Disease.- Demyelinating Disease.- Vasculitis.- SECTION X: Hybrid Imaging in Head and Neck.- Role of PET/MR in tumor staging.- Mucosal and nodal disease in the head and neck.- Extranodal disease in the head and neck.- Metastatic disease in the head and neck.- Salivary gland pathology.- Orbital pathology.- SECTION XI: Spine PET/MR.- Neoplastic Disease.- Non-Neoplastic.- SECTION XII: Vascular Hybrid Imaging.- Ischemic Disease.- Aneurysms and Vascular Malformations.- Genetic Disorders.- Perfusion and PET.- Advanced MR Techniques.- SECTIONXIII: Future Trends.- Artificial Intelligence.- Utility of AI in Dementia/Neuroimaging
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