Vitamin D

Section I: Chemistry, Metabolism, Circulation 1 Historical Overview of Vitamin D Hector F. Deluca 2 Photobiology of Vitamin D Michael F. Holick 3 The Activating Enzymes of Vitamin D Metabolism (25- and 1a-Hydroxylases) Glenville Jones and David E. Prosser 4 CYP24A1: Structure, Function, and Physiological Role Rene St. Arnaud 5 The Vitamin D Binding Protein: DBP Roger Bouillon 6 Industrial Aspects of Vitamin D Arnold L. Hirsch Section II: Mechanisms of Action 7 VDR J. Wesley Pike 8 Nuclear Vitamin D Receptor: Natural Ligands, Molecular Structure-Function, and Transcriptional Control of Vital Genes Mark R. Haussler, Carol A. Haussler, Jui-Cheng Hsieh, Peter W. Jurutka, and G. Kerr Whitfield 9 Structural Basis for Ligand Activity in VDR Dino Moras and Natacha Rochel 10 Coregulators of VDR-mediated Gene Expression Paul McDonald and Diane R. Dowd 11 Target Genes of Vitamin D: Spatio-temporal Interaction of Chromatin, VDR and Response Elements Carsten Carlberg 12 Epigenetic Modifications in Vitamin D Receptor Mediated Transrepression Shigeaki Kato, Alexander Kouzmenko, Fumiaki Ohtake, and Ryoji Fujiki 13 Vitamin D and Wnt/ß-Catenin Signaling Albert Munoz, José Manuel González-Sancho, and María Jesús Larriba 14 Vitamin D Response Element Binding Protein John S. Adams, Thomas S. Lisse, Hong Chen, Mark S. Nanes, and Martin Hewison 15 Vitamin D Sterol/VDR Conformational Dynamics and Nongenomic Actions Anthony W. Norman and Mathew T. Mizwicki Section III: Mineral and Bone Homeostasis 16 Development of the Skeleton Jane B. Lian, Gary S. Stein, Martin Montecino, Janet L. Stein, Andre J. van Wijnen 17 Vitamin D Regulation of Osteoblast Function Renny Franchesci and Yan Li 18 Osteoclasts F. Patrick Ross 19 Molecular Mechanisms for Regulation of Intestinal Calcium and Phosphate Absorption by Vitamin D James Fleet and Ryan D. Schoch 20 The Calbindins: Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6 Sylvia Christakos, Leila Mady, and Puneet Dhawan 21 Mineralization Adele Boskey and Eve Donnelly 22 VITAMIN D REGULATION OF TYPE I COLLAGEN EXPRESSION IN BONE Barbara Kream and Alexander Lichtler 23 Target Genes: Bone Proteins Howard Morris, Paul H. Anderson, Gerald J. Atkins, and David M. Findlay 24 Vitamin D and the Calcium-Sensing Receptor Edward M. Brown 25 Effects of 1,25-Dihydroxyvitamin D3 on Voltage-Sensitive Calcium Channels in Osteoblast Differentiation and Morphology Mary Farach-Carson and William R. Thompson Section IV: Targets (David/John/Wes) 26 Vitamin D and the Kidney Rajiv Kumar and Peter Tebben 27 Vitamin D and the Parathyroids Justin Silver and Tally Neveh-Many 28 Cartilage Barbara D. Boyan, Maryam Doroudi and Zvi Schwartz 29 Vitamin D and Oral Heath Ariane Berdal, Muriel Molla, Vianney Descroix 30 The Role of Vitamin D and its Receptor in Skin and Hair Follicle Biology Marie B. Demay 31 Vitamin D and the Cardiovascular System David Gardner, Songcang Chen, Denis Glenn, and Wei Ni 32 Vitamin D: A Neurosteroid Affecting Brain Development and Function; Implications for Neurological and Psychiatric Disorders John McGrath, Darryl Eyles, and Thomas Burne 33 Contributions of Genetically Modified Mouse Models to Understanding the Physiology and Pathophysiology of the 25-hydroxyvitamin D-1-alpha Hydroxylase Enzyme [1a(OH)ase] and the Vitamin D Receptor (VDR) David Goltzman, Geoffrey N. Hendy, and Richard Kremer Section V: Human Physiology 34 Vitamin D: Role in the Calcium and Phosphorus Economies Robert P. Heaney 35 Fetus, Neonate and Infant Chris Kovacs 36 Vitamin D Deficiency and Calcium Absorption During Childhood Steven A. Abrams 37 Adolescence and Acquisition of Peak Bone Mass Connie Weaver, Rick Lewis, and Emma Liang 38 Vitamin D Metabolism in Pregnancy and Lactation Bonny Specker, Natalie W. Thiex, and Heidi J. Kalkwarf 39 Vitamin D: Relevance in Reproductive Biology and Pathophysiological Implications in Reproductive Dysfunction Hugh S.