Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. As such, sections in this comprehensive book cover exciting research that shows that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues, cover FGF23 initially identified as a bone-derived factor targeting the kidney, look at FGF23 as a regulator of phosphate metabolism and beyond, and cover research on novel concepts of FGF receptor signaling. Additional sections cover biochemistry, pharmacology and nephrology, making this book an ideal reference source on FGF23.
- Provides a comprehensive collection of chapters on the diversity of FGF23's actions
- Highlights truly translational topics, from molecular signaling to physiology and mechanism of disease, discussing cell culture and animal models to study FGF23
- Describes FGF23's potential in the clinical setting as a biomarker or even drug target
- Presents leaders in the field who cover a wide spectrum of research backgrounds and expertise, including clinical and basic scientists who specialize in diseases, endocrinology, genetics, protein biochemistry, cell biology and physiology
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Illustrationen
Approx. 100 illustrations (75 in full color)
Dateigröße
ISBN-13
978-0-12-818037-2 (9780128180372)
Schweitzer Klassifikation
1. The discovery of FGF23 - a historic view: genetic disorders of hypo- and hyperphosphatemia2. FGF23 - an established master regulator of phosphate metabolism3. FGF23 - more than a phosphaturic hormone4. The regulation of FGF23 production in bone and outside of bone5. Klotho-dependent actions of FGF23 - targets, signal transduction and cellular effects6. Klotho-independent actions of FGF23 - targets, signal transduction and cellular effects7. The experimental detection of FGF23 responsiveness and effects8. FGF23 and bone disease9. FGF23 and kidney disease10. FGF23 and heart and vascular disease11. FGF23 and inflammation, anemia, and iron12. FGF23 and infectious diseases13. FGF23 and lung disease14. FGF23 and neuro-cognitive disorders15. FGF23 as a drug target16. FGF23 - resolved issues, remaining controversies and future questions - a clinician's perspective17. Klotho - the discovery of the FGF23 co-receptor18. Klotho - an FGF23-independent hormone19. Klotho and aging phenotypes20. aKlotho gene and protein measurements in humans and their role as a clinical biomarker of disease 21. Structural Basis of FGF23 Hormone Signaling22. Klotho - open questions, controversies and future perspectives23. The crosstalk between phosphate, FGF23 and klotho in the regulation of tissue homeostasis in health and disease
