Circulating Tumor Cells

Preface
Part I Introduction
1 Circulating tumor cells and historic perspectives
Jonathan W. Uhr
2 Introduction to microfluidics
Kangfu Chen, Z. Hugh Fan
Part II Isolation Methods
3 Ensemble-decision Aliquot Ranking (eDAR) for CTC Isolation and Analysis
Mengxia Zhao, Perry G. Schiro, Daniel T. Chiu
4 Sinusoidal Microchannels with High Aspect Ratios for CTC Selection and Analysis
Joshua M. Jackson, Steven A. Soper, Malgorzata A. Witek
5 Cell Separation Using Inertial Microfluidics
Nivedita Nivedita, Ian Papautsky
6 Morphological Characteristics of CTCs and the Potential for Deformability-based Separation
Simon P. Duffy, Hongshen Ma
7 Microfabricated filter membranes for capture and characterization of Circulating Tumor Cells
Zheng Ao, Anthony Williams, Richard J. Cote, Ram H. Datar
8 Miniaturized Nuclear Magnetic Resonance Platform for Rare Cell Detection and Profiling
Sangmoo Jeong, Changwook Min, Huilin Shao, Arezou Ghazani, Cesar M. Castro, Ralph Weissleder, Hakho Lee
9 NanoVelcro Cell-Affinity Assay for Detection and Characterization of Circulating Tumor Cells
An-Jou Liang, Anna Fong, Hsian-Rong Tseng, Jie-fu Chen, Millicent Lin, Min Song, Morgan Fong, Qingyu Li, Shang-Fu Chen, Sharon Chen, Shuang Hou, Yang Zhang, Zunfu Ke
10 Acoustophoresis for tumor cell enrichment
Thomas Laurell, Per Augustsson, Cecilia Magnusson, Hans Lilja
11 Photoacoustic flow cytometry for detection and capture of circulating melanoma cells
John A. Viator, Benjamin S. Goldschmidt, Kiran Bhattacharyya, Kyle Rood
12 Selectin-Mediated Targeting of Circulating Tumor Cells for Isolation and Treatment
Jocelyn Marshall, Michael King
13 Aptamers-enabled tumor cell isolation
Jinling Zhang, Z. Hugh Fan
14 Depletion of normal cells for CTC enrichment
Jeffrey J. Chalmers, Maryam B. Lustberg, Clayton Deighan, Kyoung-Joo Jenny Park, Yongqi Wu, Peter Amaya
Part III Post-Isolation Analysis and clinical translation
15 Tumor heterogeneity and single cell analysis of CTCs
Evelyn Kidess Sigal, Stefanie S. Jeffrey
16 Single-cell molecular profiles and biophysical assessment of circulating tumor cells
Chun-Liang Chen, Maria E. Gaczynska, Aaron M. Horning, Chun-Lin Lin, Anna D. Louis, Devalingam Mahalingam, Pawel Osmulski, Chiou-Miin Wang
17 Directing Circulating Tumor Cell Technologies into Clinical Practice
Benjamin P Casavant, David T Kosoff, Joshua M Lang
Part IV Commercialization
18 DEPArray(TM) Technology for Single CTC-analysis
Farideh Z. Bischoff, Nicolò Manaresi, Gianni Medoro
19 CELLSEARCH® instrument, features, and usage
Denis A. Smirnov, Brad W. Foulk, Mark C. Connelly, Robert T. McCormack
Glossary
Jose Varillas, Z. Hugh Fan
Index