Many developments in immunology have occurred over the past 10 years that give us a better understanding of the immune system and its dysfunctions. Refined mapping of the major histocompatibility complex MHC; elucidation of its gene structure and polymorphism, as well as the molecular basis of MHC restriction; the arrangement, expression, and regulation of immunoglobulins; definition of the structure of the T cell receptor and organization of its genes; and the characterization of soluble factors involved in cell/cell interactions and cloning of their genes are among the major accomplishments. Volumes I and II build on these developments in basic immunology to introduce animal models of various diseases, corresponding human studies, and the genetic analysis of autoimmune traits at the patient population level. The book will be a tremendous asset to immunologists, geneticists, and physicians in various areas of clinical subspecialties.
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978-1-040-28680-7 (9781040286807)
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Schweitzer Klassifikation
Volume I:Development of the Antibody RepertoireT Cell Antigen ReceptorsA Primer on Antigen Processing and PresentationThe T Cell Circuits - Their Defects in AutoimmunityHormones, Genes, and AutoimmunityRegulatory Idiotypes: Roles in Autoregulation and AutoimmunityNatural Autoantibodies in Regulation of Immune Homeostasis and Autoimmune DiseasesT Cell Receptor and Autoimmune DiseaseVirus-Induced AutoimmunityMHC Molecule Expression in Nonlymphoid Tissue: Implication for AutoimmunityExperimental Regulation of Autoimmune kDiseaseMajor Histocompatibility Complex Allele-Disease Associations in the Light of Extended HaplotypesTheoretical Modeling and Population Epidemiology of Complex Genetic DiseasesIndex
