Anal Canal Cancers, An Issue of Surgical Oncology Clinics of North America

Name: Anal Canal Cancers, An Issue of Surgical Oncology Clinics of North America
Brand: Elsevier
Price: 86.86 EUR
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Cathy Eng(Autor*in)

Elsevier (Verlag)

1. Auflage

Erschienen am 29. November 2016

100 Seiten

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Front Cover
Anal Canal Cancers
Copyright
Contributors
CONSULTING EDITOR
EDITOR
AUTHORS
Contents
Foreword: Anal Cancer 2016
Preface
Patient Perspective and Personal Journey of Treating a "Rare Cancer"
Epidemiology of Anal Canal Cancer
Human Immunodeficiency Virus/AIDS, Human Papillomavirus, and Anal Cancer
Anal Dysplasia
Diagnosis and Diagnostic Imaging of Anal Canal Cancer
Pathology of Anal Cancer
Treatment of the Primary Tumor in Anal Canal Cancers
Evolution and Management of Treatment-Related Toxicity in Anal Cancer
Locally Recurrent Disease Related to Anal Canal Cancers
Surveillance of Anal Canal Cancers
Metastatic Anal Cancer and Novel Agents
Uncommon Anal Neoplasms
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
FORTHCOMING ISSUES
April 2017
July 2017
October 2017
RECENT ISSUES
October 2016
July 2016
April 2016
Foreword: Anal Cancer 2016
Preface
Patient Perspective and Personal Journey of Treating a "Rare Cancer"
Key points
PERSONAL STORY: ANAL CANCER, ONLY "RARE" TO THOSE WHO DO NOT HAVE IT
CARE PROVIDERS: AWARENESS, PREVENTION, AND TREATMENT
RESEARCH: IMPROVING TREATMENT OPTIONS
THE CHALLENGE: BUILDING SUPPORT
SOLUTIONS: WHAT CAN BE DONE?
REFERENCES
Epidemiology of Anal Canal Cancer
Key points
INTRODUCTION
OVERVIEW
RISK FACTORS
Sexual Activity
Human Papilloma Virus
Human Immunodeficiency Virus
Chronic Immunosuppression
Tobacco Use
INCREASING INCIDENCE, CHANGING DEMOGRAPHICS
HUMAN PAPILLOMA VIRUS VACCINE
SUMMARY
REFERENCES
Human Immunodeficiency Virus/AIDS, Human Papillomavirus, and Anal Cancer
Key points
INTRODUCTION
ROLE OF HUMAN PAPILLOMAVIRUS INFECTION
THE ROLE OF HUMAN IMMUNODEFICIENCY VIRUS AND AIDS
TREATMENT OUTCOMES OF HUMAN IMMUNODEFICIENCY VIRUS-POSITIVE ANAL CANCERS
MANAGEMENT ISSUES IN HUMAN IMMUNODEFICIENCY VIRUS-POSITIVE PATIENTS
PREVENTION OF ANAL CANCER IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PATIENTS
SUMMARY
REFERENCES
Anal Dysplasia
Key points
DEFINITION
PREVALENCE OF ANAL DYSPLASIA
DIAGNOSTIC TESTS
TREATMENT OF ANAL DYSPLASIA
SUMMARY
REFERENCES
Diagnosis and Diagnostic Imaging of Anal Canal Cancer
Key points
INTRODUCTION
ANATOMY OF THE ANUS
CLINICAL PRESENTATION
DIAGNOSIS AND PROCEDURES
ANORECTAL ANATOMY AND IMAGING
The Sphincter Complex and Pelvic Floor
The Anal Canal
Adjacent Structures
STAGING
IMPACT OF IMAGING ON STAGING OF ANAL CANAL CANCER
Primary Anal Cancer Staging by Imaging
Nodal Spread of Anal Canal Cancer
IMAGING CHARACTERISTICS OF CLINICAL OUTCOMES
Imaging Appearances After Treatment
Imaging Features of the Pelvis During Surveillance
SUMMARY
REFERENCES
Pathology of Anal Cancer
Key points
INTRODUCTION
Normal Anatomy of the Anus
Histology Classification
Human Papilloma Virus Infection
PREINVASIVE LESIONS
Squamous Intraepithelial Lesions
Paget Disease
MALIGNANT NEOPLASMS
Squamous Cell Carcinoma
STAGING
Verrucous Carcinoma
Adenocarcinoma
OTHER TUMOR TYPES
Melanoma
Mesenchymal Tumors
Basal Cell Carcinoma of the Anus
Neuroendocrine Tumors
Undifferentiated Tumors
Secondary Tumors
IMMUNOHISTOCHEMISTRY OF ANAL CANAL CANCER
p16
MOLECULAR FEATURES OF ANAL CANAL CANCER
REFERENCES
Treatment of the Primary Tumor in Anal Canal Cancers
Key points
INTRODUCTION
STRATEGIES FOR TREATING LOCALIZED ANAL CANAL CANCER
Radical Surgery
Neoadjuvant/Induction Chemotherapy
RADIOTHERAPY
External Beam Radiation Alone
RADIOTHERAPY DOSE
ELECTIVE DOSE
BRACHYTHERAPY
MAINTENANCE/CONSOLIDATION CHEMOTHERAPY FOLLOWING CHEMORADIATION
THE OVERALL TREATMENT TIME
FIELD SIZE
TARGET DELINEATION
RATIONALE FOR CHEMORADIOTHERAPY
ORAL FLUOROPYRIMIDINES
OTHER CYTOTOXIC AGENTS
EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITION
IMMUNOTHERAPY
SUMMARY
REFERENCES
Evolution and Management of Treatment-Related Toxicity in Anal Cancer
Key points
INTRODUCTION
TOXICITY DURING THE SURGICAL ERA
FIRST-GENERATION TRIALS-RADIOTHERAPY VERSUS CHEMORADIOTHERAPY
SECOND-GENERATION TRIALS-MITOMYCIN AND CISPLATIN
Role of Mitomycin-RTOG 87-04
Roles of Cisplatin and Induction Therapy-RTOG 98-11, ACCORD 03, and ACT II
Treatment Gap
PROSPECTS OF INTENSITY-MODULATED RADIOTHERAPY
MANAGEMENT OF TOXICITIES
Hematologic
Gastrointestinal
Dermatologic
Urinary
Sexual
Quality of Life
FUTURE DIRECTIONS
Alternative Regimens and Techniques
Future Clinical Trials
SUMMARY
REFERENCES
Locally Recurrent Disease Related to Anal Canal Cancers
Key points
INTRODUCTION
SURGICAL TECHNIQUE
Preoperative Planning
History
Examination
Imaging
Multidisciplinary considerations
Informed consent
Medical optimization
Coordination of multidisciplinary team
Preparation and Patient Positioning
Surgical Approach
Exploration and/or wide local excision
Abdominal phase
Pelvic phase
Exenteration
Perineal phase
Intraoperative radiotherapy
Ilioinguinal lymphadenectomy
Soft tissue reconstruction
Immediate Postoperative Care
REHABILITATION AND RECOVERY
CLINICAL RESULTS IN THE LITERATURE
SUMMARY
REFERENCES
Surveillance of Anal Canal Cancers
Key points
INTRODUCTION
CLINICAL GUIDELINES
TIMING OF SURVEILLANCE
CLINICAL EVALUATION
IMAGING RECOMMENDATIONS
SUMMARY
REFERENCES
Metastatic Anal Cancer and Novel Agents
Key points
INTRODUCTION
EPIDEMIOLOGY
MANAGEMENT OF LOCOREGIONAL SQUAMOUS CELL CARCINOMA OF THE ANAL CANAL
MANAGEMENT OF METASTATIC SQUAMOUS CELL CARCINOMA OF THE ANAL CANAL WITH CYTOTOXIC CHEMOTHERAPY
ROLE OF BIOLOGIC AGENTS IN THE TREATMENT OF METASTATIC SQUAMOUS CELL CARCINOMA OF THE ANAL CANAL
ROLE OF SURGERY AND RADIATION IN THE MANAGEMENT OF DISTANT METASTASES
THE ROLE OF IMMUNOTHERAPY IN THE MANAGEMENT OF METASTATIC SQUAMOUS CELL CARCINOMA OF THE ANAL CANAL
REFERENCES
Uncommon Anal Neoplasms
Key points
ADENOCARCINOMA OF THE ANAL CANAL
Colorectal-Type Adenocarcinoma
Anal Gland Adenocarcinoma
Adenocarcinoma Within Anorectal Fistula
Management of Anal Adenocarcinoma
Locoregional disease
Prognosis
Metastatic disease
PAGET DISEASE OF THE ANAL CANAL
ANORECTAL MELANOMA
Pathology and Staging
Management
Locoregional disease
Adjuvant therapy
Metastatic disease
PRIMARY LYMPHOMA OF THE ANORECTAL REGION
Management
ANAL NEUROENDOCRINE TUMORS
Pathology
Management
MESENCHYMAL NEOPLASMS
Gastrointestinal Stromal Tumors
BASAL CELL CARCINOMA
METASTASES TO ANAL CANAL
SUMMARY
REFERENCES

Volume 26-1

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