Over the past several years, the pace of research on the control of axonal growth has increased at a remarkable rate, and this activity is reflected in a growing literature dealing with various aspects of axonal growth and regener ation. It appears timely to review the role played by axonal transport in the intrinsic responses of neurons in the growth and regrowth processes. Through the cooperation of the senior editors of this series, we have been given the opportunity to bring such a focus to the current volume. We wish to acknowledge that the contributing authors attended a confer ence on "The Role of Axonal Transport in Neuronal Growth and Regenera tion" held in Tallahassee, Florida in March, 1983, sponsored by the Psycho biology Research Center of the Florida State University. It is our hope that many of the perceptions and insights expressed in these chapters resulted from our interactions.
Reihe
Sprache
Verlagsort
Verlagsgruppe
Illustrationen
43
43 s/w Abbildungen
XVI, 284 p. 43 illus.
Dateigröße
ISBN-13
978-1-4684-1197-3 (9781468411973)
DOI
10.1007/978-1-4684-1197-3
Schweitzer Klassifikation
1 Axoplasmic Transport in Relation to Nerve Fiber Regeneration.- 1. Introduction.- 2. Models Proposed for Regeneration.- 3. The Transport Filament Model.- 4. Slow Transport as a Drop Off and Turnover of Components.- 5. Routing in Relation to Transport and Regeneration.- 6. A Hypothesis for Selective Neurite Growth on the Basis of Routing.- 7. References.- 2 Basic Properties of fast Axonal Transport and the Role of fast Transport in Axonal Growth.- 1. Introduction.- 2. Structures in Fast Axonal Transport.- 3. Organization of Fast Axonal Transport.- 4. Molecular Bases of Movement.- 5. Role of Fast Axonal Transport in Axonal Growth and Regeneration.- 6. References.- 3 Retrograde Signaling after Nerve Injury.- 1. Nerve Cell Body Response to Axotomy.- 2. Retrograde Axonal Transport: Physiological Significance.- 3. Chromatolysis and Retrograde Axonal Transport: Time Relationship.- 4. Possible Signal Mechanisms Mediated by Retrograde Transport.- 5. Retrograde Transport during Regeneration.- 6. Concluding Remarks.- 7. References.- 4 Retrograde Axonal Transport and Nerve Regeneration.- 1. Introduction.- 2. Retrograde Transport following Axonal Injury.- 3. Changes in Retrograde Transport during Regeneration.- 4. Control of Regeneration Rate.- 5. Conclusion.- 6. References.- 5 Biochemical Aspects of the Regenerating Goldfish Visual System.- 1. Introduction.- 2. Behavioral Evaluation of Recovered Visual Function.- 3. Expiant Culture.- 4. Retinal Incubations.- 5. Axonal Transport of Proteins Associated with Regeneration.- 6. References.- 6 Axonal Transport of Glycoproteins in Regenerating Nerve.- 1. Functions and Growth-Related Changes in Glycoproteins of Nonneuronal Cells.- 2. Glycoproteins and Neuronal Growth.- 3. Axonal Transport of Glycoproteins in Mature and Growing Neurons.- 4. Axonal Transport of Glycoproteins in Regenerating Olfactory Nerve.- 5. Conclusions.- 6. References.- 7 Transport of Transmitter-Related Enzymes: Changes after Injury.- 1. Introduction.- 2. Methods.- 3. "Cholinergic" Enzymes.- 4. Adrenergic Enzymes.- 5. Other Enzymes.- 6. Conclusions.- 7. References.- 8 Transfer-Rna-Mediated Posttranslation al Aminoacylation of Proteins in Axons.- 1. Introduction.- 2. RNA is Present in Axons.- 3. RNA in Axons Is 4 S RNA.- 4. The 4 S RNA in Axons Is Transfer RNA.- 5. Transfer RNA in Axons Serves as an Amino Acid Donor in Posttranslational Protein Modification.- 6. Posttranslational Modification of Proteins by tRNA-Dependent Amino Acid Addition Occurs in Growth Cones of Regenerating Optic Axons of Goldfish.- 7. References.- 9 Molecular Events Associated with Peripheral Nerve Regeneration.- 1. Introduction.- 2. Methods.- 3. Protein Synthesis after Nerve Damage.- 4. Proteins Transported after Nerve Damage.- 5. Axon Regrowth without Changes in Synthesis or Transport.- 6. The Fate of Axonally Transported Proteins at Regrowing Tips.- 7. Conclusions.- 8. References.- 10 Target-Dependent and Target-Independent Changes in Rapid Axonal Transport During Regeneration of the Goldfish Retinotectal Pathway.- 1. Introduction.- 2. Qualitative Studies on the Changes in Rapidly Transported Proteins during Regeneration.- 3. Target Regulation of Rapidly Transported Proteins during Regeneration.- 4. Summary and Conclusions.- 5. References.- 11 Regulation of Axon Growth and Cytoskeletal Development.- 1. Introduction.- 2. Growth-Associated Proteins and Axon Growth.- 3. Regulation of the Neurofilament Cross-Linking Polypeptide during Neuronal Development.- 4. References.- 12 Effect of a Conditioning Lesion on Axonal Transport During Regeneration: the Roleof Slow Transport.- 1. Introduction.- 2. Effects of Conditioning Lesions on Axonal Transport.- 3. Discussion.- 4. References.- 13 The Relationship of Slow Axonal flow to Nerve Elongation and Degeneration.- 1. Introduction.- 2. Influence of Temperature on Mechanisms Involved in Neuronal Maintenance and Regeneration.- 3. Changes in Axonal Transport during Development and Regeneration.- 4. Regeneration of the Garfish Olfactory Nerve.- 5. Axonal Degeneration.- 6. Conclusions.- 7. References.- 14 Neurofilament Transport in Axonal Regeneration: Implications for the Control of Axonal Caliber.- 1. Introduction.- 2. Cytoskeletal Composition in Normal Nerves.- 3. Neurofilament Transport and Axonal Caliber in Regenerating Axons.- 4. Models for the Control of Axonal Caliber by Neurofilament Transport.- 5. Conclusion.- 6. References.- 15 Calcium-Activated Protease and the Regulation of the Axonal Cytoskeleton.- 1. Introduction.- 2. Calcium-Dependent Breakdown of the Axonal Cytoskeleton.- 3. Calcium-Activated Proteolysis of Axonal Cytoskeletal Proteins.- 4. Isolation of Calcium-Activated Protease from Neural Tissues.- 5. Turnover of Neurofilament Proteins and the Regulation of the Axonal Cytoskeleton.- 6. References.
