- PART I: Monogenic Diabetes: Genetic Defects of ß-cell Development and Function
- Chapter 1: Maturity-Onset Diabetes of the Young (MODY) and Neonatal Diabetes -- 3
R. Naylor, S.A. Greeley, D. Carmody, J.L. Hwang, M. Sanyoura, L.R. Letourneau, G.I. Bell, and L. Philipson
- Part I Case Studies Introduction -- 37
- Case 1: KCNJ11 - DEND: Neonatal Diabetes -- 41
L. Letourneau, M. Sanyoura, L. Dickens, S.A. Greeley, R. Naylor, G.I. Bell, and L. Philipson
- Case 2: ABCC8 Neonatal Diabetes -- 44
L. Letourneau, M. Sanyoura, L. Dickens, S.A. Greeley, R. Naylor, G.I. Bell, and L. Philipson
- Case 3: INS - Insulin Gene Mutation in Neonatal Diabetes -- 47
L. Letourneau, M. Sanyoura, L. Dickens, S.A. Greeley, R. Naylor, GI. Bell, and L. Philipson
- Case 4: STAT3 and Neonatal Diabetes -- 51
D.W. Hansen, J.C. Sanchez, and T.S. Hannon
- Case 5: GATA6 - Heart and Pancreas -- 55
T. Triolo and K. Simmons
- Case 6: KCNJ11 R201C - Neonatal Diabetes -- 61
L.M. Nally and D.M. Wilson
- Case 7: PDX1 - Pancreatic Agenesis -- 67
M. Sanyoura, L. Letourneau, L. Dickens, S.A. Greeley, R. Naylor, G.I. Bell, and L. Philipson
- Case 8: Neonatal Diabetes and Congenital Hypothyroidism: GLIS3 -- 70
M. Sanyoura, L. Letourneau, L. Dickens, S.A. Greeley, R. Naylor, G.I. Bell, and L. Philipson
- Case 9: EIF2AK3: Wolcott-Rallison Syndrome -- 73
M. Sanyoura, L. Letourneau, L. Dickens, S.A. Greeley, R. Naylor, G.I. Bell, and L. Philipson
- Case 10: Transient Neonatal Diabetes -- 76
E.O. Buschur and K. Dungan
L. Dickens, M. Sanyoura, L. Letourneau, S.A. Greeley, R. Naylor, G.I. Bell, and L. Philipson
- Case 12: HNF1A - MODY -- 84
L. Dickens, M. Sanyoura, L. Letourneau, S.A. Greeley, R. Naylor, G.I. Bell, and L. Philipson
- Case 13: HNF4A - MODY -- 87
L. Dickens, M. Sanyoura, L. Letourneau, S.A. Greeley, R. Naylor, G.I. Bell, and L. Philipson
- Case 14: MODY as a Possible Diagnosis -- 90
I. Jamil and J.L. Gilden
- Case 15: Could This Be MODY vs. Type 2? -- 95
B.Z. Osmani, J.L. Gilden, A. Moid, and C. Harris
- Case 16: Misclassification of MODY 3 as Type 1 -- 100
L. Song, J.N. McNulty, and I. Lingvay
- Case 17: Wolfram Syndrome WFS1 -- 105
J. Sarhis-Avigdor and E. Cengi
- Case 18: Mitochondrial Diabetes -- 109
C. Sullivan and S. Alexanian
B.P. Galm, S. Sirrs, and R.O. Yeung
A.L. Frederilsen and H. Beck-Nielsen
- Case 21: Maternally Inherited Diabetes and Deafness: 23-Year Follow-Up -- 125
I. Ahmad and I.B. Hirsch
- Case 22: Glycogen Storage Type 1A Presenting with Diabetes Mellitus Type 2 -- 130
D. Sistla, M. Korytkowski, S. Mon
- PART II: Insulin Resistance, Genetic Defects in Insulin Action, and Diseases of Exocrine Pancreas
- Chapter 2: Insulin Resistance: Molecular Biology and Pathophysiology -- 135
C.L. Wang and B. Draznin
- Chapter 3: The Lipodystrophy Syndromes: Clinical Features and Treatments -- 155
M. Mattingly, A. Valencia, E. Cochran, R.J. Brown, and P. Gorden
- Chapter 4: Diabetes in Diseases of Exocrine Pancreas -- 181
J. Abramowitz, U. Gunasekaran, X.F. Samaropoulos, A. Tumyan, and I. Lingvay
- Part II Case Studies Introduction -- 215
- Case 23: Type A Insulin Resistance -- 218
A. Stears and R.K. Semple
- Case 24: Donohue Syndrome (Leprechaunism) -- 225
C. Peters and R.K. Semple
- Case 25: Rabson-Mendelhall Syndrome -- 232
R. Williams and R.K. Semple
- Case 26: Familial Partial Lipodystrophy II (Dunninan's Syndrome) -- 239
P.K. Cabandugama, S.A. Brietzke, M.J. Gardner, and J. Sowers
- Case 27: Familial Partial Lipodystrophy -- 243
K.E. Kreider and M. Feinglos
- Case 28: Severe Insulin Resistance and Lipodystrophy -- 248
K. Mekala and J. Aloi
- Case 29: Lipodystrophy Due to PPAR-¿ Gene Mutation -- 253
A. Hodes, R. Brown, E. Cochran, M. Zilbermint
- Case 30: Congenital Generalized Lipodystrophy -- 259
H. Beck-Nielsen
- Case 31: Pancreatogenic Diabetes Mellitus --263
N. Zherdeva and B. Mankovsky
- Case 32: A Case of Pancreatogenic Diabetes due to Alcohol Abuse --267
B.Z. Osmani, J.L. Gilden, and A. Moid
- Case 33: Post-Pancreatectomy Diabetes -- 273
E.D. Buras, R. Cianchandani, and J. Wyckoff
- Case 34: Diabetes and Hemochromatosis -- 277
D. Maggi, A. Aleo, L. Briatore, C. Mazzucchelli, L. Fontana, and R. Cordera
- Case 35: Bronze Diabetes -- 281
E. Meyerhoff
- Case 36: Type 2 Diabetes in Liver Cirrhosis and Hepatocellular Carcinoma -- 285
S. Ravi, A. Moid, J.L. Gilden, and D. Karam
- Case 37: Poor Glycemic Control in Insulin-Treated Diabetes Due to Anti-Insulin Antibodies -- 290
D. S. Church and R.K. Semple
- Case 38: Cystic Fibrosis-Related Diabetes -- 296
R. Iyengar, R.Y. Gianchandani, and J. Wyckoff
- Case 39: Pembrolizumab and Diabetic Ketoacidosis -- 300
F. Cottini and K. Dungan
- Case 40: Glycemic Control in Patient with Multiple Chronic Complications -- 305
A. Iqbal, J.L. Gilden, B.G. Theckadeth, S. Rapaka, and D. Dai
- Case 41: Diabetes and Exposure to Agent Orange -- 309
B.Z. Osmani, J.L. Gilden, C. Harris
- Case 42: Pasireotride-Induced Hyperglycemia -- 313
K. Brau and A. Drincic
- Case 43: Hemoglobin A1C vs. Fructosamine -- 318
A. Iqbal, J.L. Gilden, B.G. Theckadeth, S. Rapaka, and D. Dai
- Part III: Endocrinopathies, Immune-Mediated Diabetes, Diabetes of Unknown Cause, and Other Genetic Syndromes Sometimes Associated with Diabetes
- Chapter 5: Diabetes Secondary to Endocrinopathies -- 325
J. M. Silverstein, K. Sterl, J. L Cartier, P. Cruz-Bravo, C. A. Davis, S. Sadiq, and J.B McGill
- Chapter 6. Immune-Mediated Diabetes -- 357
M.F. Salam, J.W. Hughes, and J.B. McGill
- Chapter 7. Diabetes of Unknown Cause -- 383
Y. Azhar, C.A. Baker, and N. Rasouli
- Chapter 8. Genetic Syndromes Associated with Diabetes -- 395
A.C.H Wood, D. Abreu, A.L. Clark, M.A. Malbas, J.E. Sprague, and J.B. McGill
- Part III Case Studies Introduction -- 423
- Case 44: Acromegaly and Diabetic Ketoacidosis -- 426
P. Akkireddy and A. Drincic
- Case 45: Cushing's Syndrome and Diabetes -- 431
K. Peicher and L. Meneghini
Case 46: Pheochromocytoma and Diabetes -- 436
K. Modzelewski and D. Steenkamp
Case 47: Hypertension plus Hyperglycemia may be Equal to Pheochromocytoma -- 442
L.L. Yanes-Cardozo, V. Garla, and L. Lien
Case 48: Pheochromocytoma and Pre-Existing Diabetes -- 447
P. Akkireddy and A. Drincic
Case 49: Glucagonoma as a Cause of Diabetes -- 452
H. Beck-Nielsen
Case 50: Type 1 or Type 2 Diabetes vs. LADA -- 455
I. Jamil and J.L. Gilden
Case 51: LADA Masquerading as Type 2 Diabetes -- 459
N. Misaghian-Xanthos
Case 52: LADA During the Obesity Epidemic -- 462
L. Viswanathan and C. Vaz
Case 53: LADA in Older Adults -- 467
L. Viswanathan and C. Vaz
Case 54: Stiff Person Syndrome -- 472
H.N. Kim and N. Mathioudakis
Case 55: Polyglandular Failure and Diabetes -- 476
B.Z. Osmani, J.L. Gilden, A. Moid, and D. Dai
Case 56: Type B Insulin Resistance Syndrome -- 481
S. Ahern, H. Nguyen, Y. Lyou, S. Singh, and P. Wang
Case 57: Remission of Type B Insulin Resistance -- 486
J. Giordano, M.S. Kalia-Reynolds, C. Houston, R. Tanenberg, R.J. Brown, RK. Semple, and F. Cook
Case 58: Ketosis-Prone Type 2 Diabetes -- 492
J. Patel and C. Knight
Case 59: Ketosis-Prone Diabetes: Case Report -- 497
A. Milanesi and J. Weinreb
Case 60: Ketosis-Prone Diabetes Mellitus -- 501
S. Ahmed and R. Tenenberg
Case 61: Prader-Willi Syndrome -- 506
J.L. Gilden and B.Z. Osmani
Case 62: Bardet-Biedl Syndrome -- 512
J.J. Iyengar, R.Y. Gianchandani, and J. Wyckoff
Case 63: Williams-Beuren Syndrome and Diabetes -- 517
M. Gaule and A. Drincic
Case 64: Spinal and Bulbar Muscle Atrophy and Diabetes -- 522
S. Ravi, J.L. Gilden, A. Moid, B. Theckedath, and J. Afranie-Sakyi
Index -- 527
