Microneedles for Drug and Vaccine Delivery and Patient Monitoring

Name: Microneedles for Drug and Vaccine Delivery and Patient Monitoring
Brand: Wiley-ISTE
Price: 139.99 EUR
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Ryan F. Donnelly Thakur Raghu Raj Singh Eneko Larraneta Maeliosa T. C. McCrudden(Herausgeber*in)

Wiley-ISTE (Verlag)

1. Auflage

Erschienen am 1. Juni 2018

352 Seiten

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978-1-119-30516-3 (ISBN)

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Inhalt

Cover
Title Page
Copyright
Contents
List of Contributors
About the Editors
Preface
Chapter 1 Genesis of Transdermal Drug Delivery
1.1 Skin Anatomy
1.1.1 The Epidermis
1.1.2 The Stratum Corneum
1.1.3 The Dermis
1.1.4 Skin Appendages
1.2 Routes to Percutaneous Drug Absorption
1.3 Facilitated Transdermal Drug Delivery
1.3.1 Electrical-based Devices
1.3.1.1 Iontophoresis
1.3.1.2 Electroporation
1.3.1.3 Ultrasound
1.3.1.4 Cryopneumatic and Photopneumatic Technologies
1.3.1.5 Velocity-based Devices
1.3.1.6 Thermal Approaches (Lasers and Radiofrequency Heating)
1.3.1.7 Microneedles
References
Chapter 2 Microneedle Manufacturing and Testing
2.1 Introduction
2.2 Material Types, Properties and Biocompatibility
2.2.1 Silicon
2.2.1.1 Biocompatibility of Silicon
2.2.2 Metals
2.2.2.1 Biocompatibility of Metals
2.2.3 Ceramics
2.2.3.1 Biocompatibility of Ceramics
2.2.4 Silica Glass
2.2.4.1 Biocompatibility of Silica Glass
2.2.5 Carbohydrates
2.2.5.1 Biocompatibility of Carbohydrates
2.2.6 Polymers
2.2.6.1 Biocompatibility of Polymers
2.3 Microneedles Manufacturing and Design
2.3.1 Basics of Microfabrication
2.3.1.1 Lithography and Etching
2.3.1.2 Thin-film Deposition on Substrates
2.3.1.3 Etching
2.3.2 Microfabrication MNs
2.3.2.1 Fabrication of Silicon MNs
2.3.2.2 Fabrication of Metal and Glass MNs
2.3.2.3 Fabrication of Polymeric MNs
2.3.3 Microneedle Design
2.4 Microneedle Mechanical Characterisation
2.4.1 Axial Force Microneedle Mechanical Tests
2.4.2 Transverse Force and Shear Strength Microneedle Mechanical Tests
2.4.3 Baseplate Strength and Flexibility Tests
2.4.4 Microneedle Insertion Measurements
2.4.4.1 Staining of Microneedle-treated Skin
2.4.4.2 Transepidermal Water Loss Measurements
2.4.4.3 Electrical Impedance Measurements
2.4.4.4 Histological Tissue Staining and Sectioning
2.4.4.5 Confocal Microscopy
2.4.4.6 Optical Coherence Tomography
2.4.5 Significance of Microneedle Test Results
References
Chapter 3 Microneedle-mediated Drug Delivery
3.1 Introduction
3.2 Microneedle Drug Delivery Strategies
3.2.1 Solid Microneedles
3.2.2 Coated Microneedles
3.2.3 Hollow Microneedles
3.2.4 Dissolving Microneedles
3.2.5 Hydrogel-forming Microneedles
3.3 Conclusion
References
Chapter 4 Microneedle-mediated Vaccine Delivery
4.1 Introduction
4.2 Vaccine Delivery
4.2.1 Vaccination
4.2.2 Alternative Vaccine Delivery Options
4.3 Intradermal Vaccination
4.3.1 Skin Structure
4.3.2 Skin Immune Response
4.3.3 Conventional Strategies for Intradermal Vaccine Delivery
4.4 MN Delivery of Vaccine Therapeutics
4.4.1 Dissolving/Biodegrading Polymeric MNs
4.4.1.1 Viral Vaccines
4.4.1.2 Bacterial Vaccines
4.4.1.3 Model and Novel Vaccines
4.4.2 Hollow MNs
4.4.3 Solid MN
4.4.3.1 "Poke and Patch" Methodologies
4.4.3.2 Coated MNs
4.5 Future Perspectives
References
Chapter 5 Microneedles for Gene Therapy: Overcoming Extracellular and Intracellular Barriers
5.1 Gene Therapy
5.2 DNA Vaccination
5.2.1 Advantages of DNA Vaccination
5.2.2 Mechanism of Action of DNA Vaccines
5.3 Treatment of Local Skin Diseases
5.4 Limitations of Gene Therapy
5.5 Microneedles as a Physical Delivery Strategy for Gene Therapy
5.5.1 Solid Microneedles
5.5.2 Coated Microneedles
5.5.3 Hollow Microneedles
5.5.4 Dissolvable Microneedles
5.5.5 Microneedles in Combination with Other Delivery Technologies
5.5.5.1 In Combination with Physical Delivery Technologies
5.5.5.2 In Combination with Vector-based Delivery Technologies
5.6 Conclusions
References
Chapter 6 Delivery of Nanomedicines Using Microneedles
6.1 Introduction
6.2 Skin Structure and Barrier Properties Which Impact on Nanoparticle and Microparticle Penetration
6.3 Conventional Nanocarriers for Topical and Transdermal Delivery
6.3.1 Lipidic Vesicles
6.3.2 Lipid Nanoparticles
6.3.3 Polymeric Nanoparticles and Microparticles
6.3.4 Microemulsions
6.3.5 Metallic and Mineral Nanoparticles
6.4 Microneedle-mediated Transdermal Delivery of Nanoparticles and Microparticles
6.4.1 Microneedle-assisted Nanoparticle/Microparticle Permeation
6.4.2 Drug Delivery
6.4.3 Vaccine Delivery
6.4.4 Other Uses
6.5 Conclusions
References
Chapter 7 Minimally-invasive Patient Monitoring and Diagnosis Using Microneedles
7.1 Introduction
7.1.1 What is Patient Monitoring?
7.1.2 Why is Patient Monitoring Useful?
7.1.3 Limitations and Challenges of Therapeutic Monitoring
7.2 Sampling Techniques
7.2.1 Minimally and Non-invasive Sample Extraction
7.2.2 Microneedles and Fluid Sampling Technology
7.3 Microneedle Fluid Extraction Device Technical Considerations
7.3.1 Mechanical Parameters
7.3.2 Fluidics
7.4 Microneedle Innovations
7.4.1 Glucose Monitoring
7.5 Microneedle Innovations in Analyte Monitoring
7.5.1 Therapeutic Drug and Biomarker Detection
7.6 Microneedle Electrode Technology
7.6.1 Electro-biochemical Monitoring
7.7 Sampling and Analytical Systems Integration
7.7.1 Limitations and Challenges Associated with Systems Integration
7.8 Interstitial Fluid and Blood Sampling
7.8.1 Devices and Patents
7.9 Developments Moving Forwards
7.9.1 Industrialisation and Commercialisation: Hurdles to Overcome
7.10 Conclusion
References
Chapter 8 Delivery of Photosensitisers and Precursors Using Microneedles
8.1 Introduction
8.1.1 Photodynamic Therapy
8.1.2 Photosensitisers
8.2 Topical Application of Photodynamic Therapy
8.3 Methods to Enhance Topical Photodynamic Therapy
8.3.1 Microneedle-mediated Photodynamic Therapy
8.3.2 Photodynamic Therapy and Skin Pre-treatment Using Microneedles
8.3.3 Delivery of Photosensitisers Using Microneedles Containing the Active Agent
8.4 Microneedles and Photothermal Therapy
8.5 Conclusion
References
Chapter 9 Microneedles in Improving Skin Appearance and Enhanced Delivery of Cosmeceuticals
9.1 Introduction
9.2 The Skin
9.3 Microneedling Technologies: An Evolutionary Step Towards MN Usage
9.4 Benefits of Microneedling
9.5 Commercially Available MN Devices
9.5.1 Dermaroller®
9.5.2 Beauty Mouse®
9.5.3 DermastampT
9.5.4 Dermapen®
9.5.5 Light Emitting MN Devices
9.6 Patient Factors Relating to MN Devices
9.6.1 Acceptability of MN Devices by Patients and Healthcare Providers
9.6.2 Potential Irritation and Erythema
9.6.3 Patient Safety
9.6.4 Sterilisation Considerations
9.7 Delivery of Cosmeceutical Compounds
9.7.1 A Role for Hyaluronic Acid in MN Delivery Systems
9.7.2 MN-mediated Peptide Delivery
9.7.3 The Delivery of Other Cosmeceutical Agents
9.8 Recent Developments
9.8.1 Human Stem Cells
9.8.2 Fractional Radiofrequency
9.9 Conclusion
References
Chapter 10 Microneedles for Ocular Drug Delivery and Targeting: Challenges and Opportunities
10.1 Introduction
10.2 Anatomy of the Eye and Barriers to Drug Delivery
10.2.1 The Anterior Segment and its Barrier Function
10.2.2 The Posterior Segment and its Barriers Function
10.3 Ocular Diseases and Treatments
10.4 Current Ocular Drug Delivery Systems and Administration Routes
10.4.1 Topical Route
10.4.2 Oral/Systemic Administration Route
10.4.3 Ocular Injections
10.4.3.1 Anterior Segment Injections
10.4.3.2 Posterior Segment Injections
10.5 Microneedles in Ocular Drug Delivery
10.5.1 Hollow MNs
10.5.2 Solid MNs with "Coat and Poke" Strategy
10.5.3 Dissolving MNs
10.5.4 Hollow MN Strategy
10.5.5 Other Strategies
10.6 MN Application Devices
10.7 MN Safety Concerns
10.8 Conclusion
References
Chapter 11 Clinical Translation and Industrial Development of Microneedle-based Products
11.1 Introduction
11.2 Materials
11.3 Other Potential Applications
11.4 Patient Application
11.5 Patient/Healthcare Provider Acceptability
11.6 Patient Safety
11.7 Manufacturing and Regulatory Considerations
11.8 Commercialisation of MN Technologies
11.9 Conclusion
11.10 Future Perspectives
References
Index
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