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This handy volume, that can also serve as an integration to the preceding work Cellular Primary Immunodeficiencies by the same editor, presents detailed state of the art knowledge on Severe Combined Immunodeficiency (SCID) with extensive coverage of both basic science discoveries and the latest clinical advances in the field. The book is structured according to the most recent classifications including update on the immunological synapse, as well as on bioinformatics in primary immunodeficiencies leading the reader towards the computational immunology era. Readers will also find in-depth descriptions of SCID genes and related clinical application, and aspects such as differential diagnosis, clinical management, and the role of vaccines are also addressed. The authors are recognized experts world-wide and have crafted their chapters to turn Severe Combined Immunodeficiency in a valued, compact update for immunologists, paediatricians, internists, rheumatologists, and infectious diseases specialists, that MDs and PhD students will find informative as well.
Mario Milco D'Elios is full Professor and Chair of General Pathology & Immunology at the University of Siena and Specialist in Clinical Immunology and Medicine. After obtaining his degree cum laude in Medicine and Surgery from the University of Florence (1990), he specialized with honors in Allergology and Clinical Immunology (1993) at the same university. Member of Italian Society of Clinical Immunology and Allergy, he is also member of the European Scientific Committee on Gastrointestinal lymphomas since 2006 and member of the European Scientific Group on Immunology of Helicobacter pylori infection since 2004. Professor of General Pathology and Immunology, and Principal Investigator at the University of Siena, his fields of expertise are immunodeficiency, mucosal immunology, T cells, and he has published over 200 scientific papers in the field of immunology and immunodeficiency.
Preface.- 1. Mucosal Immunity in Primary Immunodeficiencies.- 2. Genetic defects associated with SCID and their impact on lymphocyte development .- 3. Bioinformatics in primary immunodeficiencies: Towards a "computational immunology" era.- 4. Clinical management of severe combined immunodeficiencies .- 5. Hot topics in SCID .- 6. Late-onset and hypomorphic presentation of severe combined immune deficiency.- 7. Gut involvement in Cellular Immunodeficiencies.- Subject index.
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