Evolutionary Systems Biology

Part 1. Theory and philosophy.- Biology as a process and the consequences for studying it.- Capturing the genotype-phenotype map with the adaptive multiscape.- Evolution plays a high-dimensional game.- What is next for evolutionary systems biology?.- Part 2. Single celled organisms.- Experimental evolution of microbial host-parasite relations.- Engineering microbial communities that evolve in a spatial setting.- Sharing is caring: differential gene flow in microbial communities.-Synthetic biology to study the evolution of gene regulatory networks.- Evolution of stem cell differentiation.- The evolution of epigenetic switches and cellular clocks.- Part 3. Multicellular organisms.- Measuring the genotype-phenotype map in eukaryotes.- Pigment evolution in Drosophila fly species: time for theory?.- Birds of a feather: using experiment and theory to understand the evolution of feather patterning.- A regulatory network that explains both fish fins and mouse limbs.- Quantitative system driftof the fly body plan.- Part 4. Immunity and disease.- Of mice, men, and immunity.- Immunity as an evolving adaptive system.- Cancer is a microevolutionary systemic disease.- A systems approach to cancer.