Modern Tools for the Synthesis of Complex Bioactive Molecules

FOREWORD vii
PREFACE ix
CONTRIBUTORS xi
CHAPTER 1 C-H FUNCTIONALIZATION: A NEW STRATEGY FOR THESYNTHESIS OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS 1
Sophie Rousseaux, Benoy^t Lie´gault, and KeithFagnou
CHAPTER 2 THE NEGISHI CROSS-COUPLING IN THE SYNTHESIS OF NATURALPRODUCTS AND BIOACTIVE MOLECULES 33
Evelina Colacino, Jean Martinez, and Fre´de´ricLamaty
CHAPTER 3 METAL-CATALYZED C-HETEROATOM CROSS-COUPLINGREACTIONS 77
Renata Marcia de Figueiredo, Jean Marc Campagne, and DamienPrim
CHAPTER 4 GOLDEN OPPORTUNITIES IN THE SYNTHESIS OF NATURALPRODUCTS AND BIOLOGICALLY ACTIVE COMPOUNDS 111
Fabien Gagosz
CHAPTER 5 METATHESIS-BASED SYNTHESIS OF COMPLEX BIOACTIVES155
Jean-Alexandre Richard, Sin Yee Ng, and David Y.-K. Chen
CHAPTER 6 ENANTIOSELECTIVE ORGANOCATALYSIS: A POWERFUL TOOL FORTHE SYNTHESIS OF BIOACTIVE MOLECULES 189
Mitsuru Shoji and Yujiro Hayashi
CHAPTER 7 ASYMMETRIC PHASE-TRANSFER CATALYSIS 213
Seiji Shirakawa, Shin A. Moteki, and Keiji Maruoka
CHAPTER 8 REARRANGEMENTS IN NATURAL PRODUCT SYNTHESIS 243
Jose´ Marco-Contelles and Elena Soriano
CHAPTER 9 DOMINO REACTIONS IN THE ENANTIOSELECTIVE SYNTHESIS OFBIOACTIVE NATURAL PRODUCTS 271
Lutz F. Tietze, Scott G. Stewart, and AlexanderDu¨fert
CHAPTER 10 FLUOROUS LINKER-FACILITATED SYNTHESIS OF BIOLOGICALLYINTERESTING MOLECULES 335
Wei Zhang
CHAPTER 11 THE EVOLUTION OF IMMOBILIZED REAGENTS AND THEIRAPPLICATION IN FLOW CHEMISTRY FOR THE SYNTHESIS OF NATURAL PRODUCTSAND PHARMACEUTICAL COMPOUNDS 359
Rebecca M. Myers, Kimberley A. Roper, Ian R. Baxendale, andSteven V. Ley
CHAPTER 12 SYNTHETIC APPROACHES TO BIOACTIVE CARBOHYDRATES395
Xavier Guinchard, Se´bastien Picard, and DavidCrich
CHAPTER 13 AMMONIUM YLIDES AS BUILDING BLOCKS FOR ALKALOIDSYNTHESIS 433
Scott Bur and Albert Padwa
CHAPTER 14 PRECURSOR-DIRECTED BIOSYNTHESIS OF POLYKETIDE ANDNONRIBOSOMAL PEPTIDE NATURAL PRODUCTS 485
Colin J. B. Harvey and Chaitan Khosla
CHAPTER 15 TARGET-ORIENTED AND DIVERSITY-ORIENTED ORGANICSYNTHESIS 513
Raphae¨l Rodriguez
CHAPTER 16 DNA AS A TOOL FOR MOLECULAR DISCOVERY 539
Michael Smietana, Jean-Jacques Vasseur, Janine Cossy, andStellios Arseniyadis
INDEX 557