Montreal, Canada, June 15-20, 1986

Name: Montreal, Canada, June 15-20, 1986
Brand: De Gruyter
Price: 304.95 EUR
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B. A. Cooper V. M. Whitehead(Herausgeber*in)

De Gruyter (Verlag)

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Erschienen am 22. Juli 2019

XXVIII, 1050 Seiten

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Intro
Preface
Acknowledgments
Contents
How it all Began: A Brief History of the Pteridine Symposia
The Gowland Hopkins Lecture: The Mechanisms of Action of Folate and Pterin Requiring Enzymes
Section A: Chemistry of Pterins and Folates
Side-Chain Chemistry of Pteridines
A General Method for the Synthesis of 10-Substituted-10-Deaza Folate Analogues
Synthesis and Properties of Pyrimidodiazepines as Ring-Strained Probes of Pterin Utilizing Enzymes
Summary: Pterin and Folate Chemistry
A Facile Method for Preparing 2,4-Diamino-5,8-Dideazapterins
Synthesis of 5,10-Dideaza-5,6,7,8-Tetrahydrofolic Acid (DDATHF) and Analogs
Synthetic Routes to Methotrexate- and Folic Acid-Polyglutamates of High Chemical and Enantiomeric Purity
In Vivo and In Vitro Evaluations of 5-[4-(Substituted Aryl)-1- Piperazinyl]-6-Alkyl-2,4-Pyrimidinediamines as Antitumor Agents
The Electrochemical Oxidation of Tetrahydropterin Derivatives
A Practical Synthesis of (6R)- and (6S)-5,6,7,8-Tetrahydrobiopterins
Chemical Synthesis and Properties of Quinonoid (6R)-Dihydrobiopterin
Pyrazine-Ring Conformations of Tetrahydropterins and Quinonoid-Dihydropterins
Hydrogenation of Silylated Pterins in Benzene Solution
N(5)-Alkylation of Polyacetylated 5,6,7,8-Tetrahydroneopterins
Oxidations Photosensitized by Pterins and Diaminopteridines
Structure of the Riboflavin Synthase/Lumazine Synthase Complex. Arrangement and Chain Folding of Subunits in the Icosahedral Capsid
Use of C18 Silica Cartridges to Purify and Characterize Pterins
Synthesis and Structure-Activity Relationships of Tetrahydrobiopterin Cofactor Analogues
Synthesis, Purification and Properties of a New Class of Pteridine Derivatives
Summary: Chemistry of Pterins
Section B: Biosynthesis and Biochemistry of Pterins
Biosynthesis of Tetrahydrobiopterin and Related Compounds in Drosophila melanogaster
Tetrahydrobiopterin Biosynthesis in Man
The Biosynthesis of Tetrahydrobiopterin in the Bovine Adrenal Medulla
The Biosynthesis of Tetrahydrobiopterin in Rat Brain
Summary: Biosynthesis of Tetrahydrobiopterin
The Metabolic Role of Tetrahydrobiopterin
Spectroscopic Studies on Tyrosine 3-Monooxygenase from Bovine Adrenal Medulla: A Blue Iron Protein
Queuine-Lacking tNRAs in Relation to the Grade of Malignancy of Specific Tumors, Possible Role of Pteridines
Pteridine Synthesis During Interaction of Interleukin 2 with T Lymphocytes - Modulator Function in IL-2 Signal Transmission
Section C: Biology of Pterins
Dopamine Neurons in Culture: A Model System for Examination of Neuronal Biopterin Metabolism
Role of the Pituitary in the Regulation of Tetrahydrobiopterin Biosynthesis in the Non-Neuronal Tissues
Distribution of GTP Cyclohydrolase-I, Neopterin, and Biopterin in the Human Brain
Enzymatic Synthesis of 6,7-Dimethyl-8-Ribityllumazine
A Model for Hyperphenylal aninaemia Due to Tetrahydrobiopterin Deficiency
The Effect of Biopterin and its Reduced Derivatives on Cultured Human Lymphocytes
Developmental Aspects of Biopterin Metabolism in Human
Screening for Biopterin Defects Among Hyperphenylalaninemic Patients: Report of a Canadian Program After 3 Years
Need for Therapy in utero of Fetuses with Tetrahydrobiopterin Deficiency
Pteridine Metabolism in Patients Suffering from Amyotrophic Lateral Sclerosis
Urinary Neopterin in Cocaine-Abusing Individuals
Features of Neopterin Determination in Clinical Use
Diurnal Variation in Urinary Pterin Excretion in Man
The Relationship between Pteridines and Colour Dimorphism in the Scorpion Fly
Pteridine Biosynthesis and Manifestation of Pigment Phenotypes in Normal and Neoplastic Cells of Goldfish in Vitro
Light Depending Regulations of Pteridines in the Retina
Differences in the Regulation of Tetrahydrobiopterin Biosynthesis in Neuronal Cells in Culture
NADPH- and NADH-Specific Dihydropteridine Reductase in Teratocarcinoma Cells in Culture: Effect of Nerve Growth Factor Treatment of the Cells on the Enzyme Activities
Reversibility of a-Diketo Reductase Activity by Sepiapterin Reductase
Non-Enzymatic Synthesis of "Drosopterins" from Dihydropterin and 2-Amino-4-0xo-6-Acetyl-3H, 9H-7,8-Dihydropyrimido [4,5b] [1,4]Diazepine
BH4 Biosynthesis: ⊃&1&/sup&H-NMR Evidence for the Pyruvoyl-Tetrahydropterin-Synthase Catalyzed Formation of 6-Pyruvoyl-Tetrahydropterin from Dihydroneopterin Triphosphate
Catabolism of Tetrahydrobiopterin in Man
Pteridine Biosynthesis in Human Amniocytes and Chorionic Villi
The Role of the Kidney in Biopterin Metabolism
Tetrahydrobiopterin-Producing Enzyme Activities in Liver of Animals and Man
Effect of 3-Hydroxykynurenine on GTP Cyclohydrolase Activity and on the Pteridine Pattern in Drosophila melanogaster
Tetrahydrobiopterin Metabolism in Normal Brain, Senile Dementia of the Alzheimer Type and Down's Syndrome
Summary: Biology of Pteridines
Biosynthesis of Pteridines and Metabolism of Aromatic Amino Acids in Drosophila melanogaster
The Inhibition of tRNA Transglycosylases by Pteridines as a Mean for Metabolic Control of Gene Expression
Modulation of Dopamine Synthesis by Nerve Terminal Autoreceptors: A Role for Tetrahydrobiopterin?
A Monoclonal Antibody Reacting with All Three Aromatic Amino Acid Hydroxylases
Alterations in Cofactor-Dependent Activity of Phenylalanine Hydroxylase as a Function of pH
Interaction of a Monoclonal Antibody with Rat Liver Phenylalanine Hydroxylase
The Effect of Dietary Iron on the Activity of Rat Liver Phenylalanine Hydroxylase
Strict Requirement of Fe⊃&2+&/sup& for Tryptophan 5-Monooxygenase from Mouse Mastocytoma, P-815
Tetrahydrobiopterin and the Regulation of Catecholamine Synthesis in Bovine Adrenal Medullary Chromaffin Cells
Cofactor Activity of Tetrahydropterins for Tyrosine Hydroxylation in PC12 Pheochromocytoma Cells
Summary: Pterin-Dependent Biological Reactions
Tetrahydrobiopterin Deficiency. Analysis from an International Survey
Cofactor Specificity of 6,6-Disubstituted Tetrahydropterins, and their Potential in the Treatment of Neurological Disorders
Normal Concentrations of Tetrahydrobiopterin in the Cerebrospinal Fluid of Patients with Dihydropteridine Reductase Deficiency
Prenatal Diagnosis of Tetrahydrobiopterin Deficiency
Defective Biopterin Biosynthesis in a Chinese Infant
Correlation of Dihydropterine Reductase Cross Reacting Material with Non-Responsiveness to a Tetrahydrobiopterin Load
Neopterin and Dihydroneopterins in Serum of Controls and Patients with Various Diseases. Circadian Rhythm of Neopterin. Influence of Cortisol?
Neopterin Content and GTP-Cyclohydrolase Activity of Blood Cells of Controls and Patients Positive for LAV/HTLV-III Antibodies
Neopterin in Bone Marrow Transplant Monitoring: An Improvement in its Use for GVHD Diagnosis
Importance of Neopterin Determination in Individuals at Risk for AIDS
Biochemical Aspects of Pteridines During Interaction Between Activated T-Lymphocytes and Monocytes/Macrophages in Patients
Summary: Pterins and Human Illness
Section D: Folates and Pterins in Mammalian Tissues
Folates in Tissues and Cells. Support for a "Two-Tier" Hypothesis of Regulation of One-Carbon Metabolism
Elevation in the Rate of Cellular Folate Catabolism in Mid-Pregnancy in the Rat
The Red Blood Cell as a Storage Site for Folic Acid
Methotrexate and Biopterin Levels in Blood Following Low Dose Administration for Psoriasis
Summary: Folates in Tissue and Cells
Folate Rescue of N⊂&2&/sub&O-Induced Inhibition in Murine Lymphocytes
Folate Absorption and Metabolism in Alcohol Fed Rats
Chronic and Acute Effects of Ethanol on Renal Clearance and Urinary Excretion of Folate in Rats
Effect of Chronic Anticonvulsant Treatment on Folate Concentrations in the Rat
Alcohol Induced Methyl Group Wastage as a Possible Cause of Fatty Liver
Folate Catabolism in the Syrian Golden Hamster
The Level of Folate Catabolism in Normal Human Populations, Suggesting that the Current Level of RDA for Folate is Excessive
Microdetermination of Folate Monoglutamates in Serum by High-Performance Liquid Chromatography with Electrochemical Detection
Folate Status in Psychiatric Patients: Relationship with CSF Neurotransmitter Metabolites
Folate, Thiamine and Vitamin B⊂&12&/sub& Levels in Outpatient Epileptics
Effect of Aspirin Ingestion on Folate Bioavailability Evaluated by Rat Liver Bioassay
Brush Border Pteroylpolyglutamate Hydrolase in Pig Jejunum
Use of CI-920 in the Characterization of the Methotrexate Transport Defect in a Resistant Human Leukemic CCRF-CEM Cell Line
The Effect of Oxidative Stress on Methotrexate (MTX) Transport by Rat Hepatocytes
Folate Transport by Pig Intestinal Brush Border Vesicles
Depressed Folate Transfer Across the Mammary Gland Secondary to Iron Deficiency in the Rat
Studies on the Mechanism of Folate Transport in Isolated Hepatocytes
Analysis of the pH and Na⊂&+&/sub& Dependence of Intestinal Folate Transport
Intestinal Transport of Folate. Characterization of the Transport Events at the Brush Border and the Basolateral Membranes
The Synthesis of Some Novel Probes of Folate Transport and Binding
Photoaffinity Probes of Dihydrofolate Reductase and of the Membrane Carrier for Folate Analogues
The Use of Biosynthetic Radioactive Folylpolyglutamates to Study Intestinal Digestion and Absorption of Folate
Selective Inhibition of Bacterial Carboxypeptidase G and Pancreatic Conjugase by 2-Mercaptomethylglutaric Acid
Summary: Folate Absorption and Transport
Studies on Glycine-N-Methyltransferase
Folate Binding Protein from Pediococcus Cerevisiae Strains Possessing Active Transport Systems for Folates
Immobilized Folate Binding Protein from Cow's Milk Used for Quantitation of Folate
Characterization of Rabbit Antibodies Against the Folate Binding Protein from Cow's Milk
Section E: Enzymology of Folates
1. Thymidylate Synthase
Genetic and Chemical Studies on Thymidylate Synthase
Active Site Probes of Thymidylate Synthetase
Resonance-Raman Spectroscopic Identification of the Transient Intermediates Formed in the Native Ternary Complex with Thymidylate Synthase
The Reversal of the Cytotoxicity of Folate-Based Thymidylate Synthase Inhibitors in Cultures L1210 Cells
Thymidylate Synthase Activity in the Tapeworm, Hymenolepis diminuta
Identification of Poly G Bound to Thymidylate Synthase
Methotrexate Derivates of Deoxyuridylate Showing Inhibitory Properties for Thymidylate Synthetase from Lactobacillus casei
Comparison of Thymidylate Synthase Isolated from Mouse Normal and Tumour Tissues
Thymidylate Synthase Interaction with Analogues of dUMP and 5-Fluorid- 2'-Deoxyuridine-5'-Phosphate with Modified Phosphate Groups
An In Vitro System for Studies on Inhibition of the Thymidylate Cycle
N⊃&10&/sup&-Propargyl-5,8-Dideazafolic Acid Polyglutamates as Inhibitors of Thymidylate Synthase and their Intracellular Formation
Sequential CMF in Metastatic Breast Cancer: An Attempt to Increase Effectiveness by Means of Biochemical Modulation
Model Studies of Thymidylate Synthase Reaction
Synergistic Interaction Between Folinic Acid and the Fluoropyrimidines
2. Methionine Biosynthesis
Methionine Biosynthesis
Impaired Formylation and Uptake of Tetrahydrofolate by Rat Small Gut Following Cobalamin Inactivation
Heterogeneity in Functional Methionine Synthase Deficiency
Summary: Methionine Biosynthesis
3. Folyl Polyglutamate Synthetase
Folylpoly-?-glutamate Synthetase
Cytotoxic Effects and Inhibition of Folylpolyglutamate Synthetase by Folate Analogs Containing 2, Omega-Diaminoalkanoic Acids
An Upstream Gene Regulates the Expression of Folylpolyglutamate Synthetase-Dihydrofolate Synthetase in Escherichia coli
Occurence and Synthesis of Pteroyl-?-glutamyl-?-glutamyl-poly-a-glutamates in Escherichia coli
Summary: Folylpolyglutamate Synthesis
The Metabolism of Pteroylpolyglutamates
Dihydropteroyl Hexaglutamate and T4 Phage Baseplate Assembly
Effects of Polyglutamylation on Folate Cofactor and Antifolate Activity in the Thymidylate Synthase Cycle of Permeabilized Murine Leukemia L1210 Cells
Summary: Pteroylpolyglutamate metabolism
4. Dihydrofolate Reductase
Recent Advances in the Study of Dihydrofolate Reductase
The 2.8 Å Structure of a Type II Plasmid Encoded Dihydrofolate Reductase
Mutations in the Human Dihydrofolate Reductase
Theoretical Studies of the Structure, Conformational and Electronic Properties of Anticancer Folate Inhibitors
Binding of Inhibitors with Spin-Labeled Side Chains to Dihydrofolate Reductase (DHFR) from Several Species
Affinity Labeling of Dihydrofolate Reductase with an Iodoacetyl Lysine Analogue of Methotrexate
Escherichia coli Dihydrofolate Reductase Isolated as a Folate Complex
Dihydrofolate Reductase from Soybean Seedlings
Use of Antibodies as Structural Probes of Dihydrofolate Reductases and Enzyme-Ligand Complexes
Cooperativity in Inhibitor Binding to Neisseria gonorrhoeae Dihydrofolate Reductase
pH Studies of the Reaction Catalyzed by Dihydrofolate Reductase from E. coli
Effects of pH on Reactions Catalyzed by Dihydrofolate Reductase from Chicken Liver
Unconjugated Dihydropterin Substrates for Bovine Liver Dihydrofolate Reductase
Enzymatic Characterization of Recombinant Human Dihydrofolate Reductase Produced in E. coli
Levels of Folates and Methotrexate Polyglutamate Formation in Chinese Hamster Ovary Cells Lacking Dihydrofolate Reductase
Methotrexate in Adjuvant Arthritis
Computer Graphic Modeling in Drug Design: Conformational Analysis and Active-Site Modeling of Lipophilic Diaminopyrimidines
Effect of Antifolates 10-Methyl- and 10-Ethyl-10-Deaza-Aminopterin on a Human Breast Cancer Cell Line
Biochemical and Cytotoxic Effects of the Erythro- and Threo-Isomers of Gamma-Fluoro-Methotrexate
5. Other Folate Enzymes
C⊂&1&/sub&-Tetrahydrofolate-Synthase, a Multifunctional Enzyme Involved in Purine Metabolism, and its Related Monofunctional Enzymes
The Interaction of Tetrahydropteroylpolyglutamates with 10-Formyltetra-Hydrofolate Synthetase
Summary: Folates in C 1 Metabolism
Chemical Aspects of Dimethylglycine Dehydrogenase and Sarcosine Dehydrogenase
Folate Normalizes Elevated PRPP Levels of Folate-Deficient HL-60 Cells
Stereochemistry of Hydride Transfer to NADP+ by Methylene Tetrahydrofolate Dehydrogenase from Pig Liver
The Effects of Thyroxine Status on Hepatic Levels of 10-Formyltetrahydrofolic Acid: NADP Oxidoreductase
Interaction of Homocysteine with Methionine Synthetase
Minor Form of Human Hepatic Betaine: Homocysteine S-Methyltransferase
Studies of Cobalamin-Dependent Methionine Synthase from Escherichia coli B
Inhibition of Methylenetetrahydrofolate Reductase by Adenosyl Methionine
Regulation of Folate Homeostasis
An Endogenous Inhibitor of Neurospora Folylpolyglutamate Synthetase
Folylpolyglutamate Hydrolase from Beef Liver
Use of Mammalian Cell Transformation to Isolate Genomic Sequences Encoding Human Folylpolyglutamate Synthetase (FPGS) and Dihydrofolate Reductase (DHFR)
Section F: Methotrexate and Other Anti-Folates
Antifolates: Expanding Horizons in 1986
Deaza Derivatives of Tetrahydrofolic Acid. A New Class of Folate Antimetabolite
Structure Activity Relationships of Novel Triazine Antifolates
The Effect of 7-Hydroxymethotrexate on the Antitumor Activity and Host Toxicity of Methotrexate In Vivo
Summary: The Biology of Antifolates
Crystal Structure of Methotrexate and its Conformational Comparison with Related Structures
Effect of Methotrexate on Reduced Folates and Thymidylate Synthesis During Growth of L1210 Cells
Dihydrofolate Reductase from Human Osteosarcoma Cells Resistant to Methotrexate
Evidence for Direct Inhibition of Metabolic Pathways as a Mechanism of Action of Methotrexate
Inhibition of Dihydrofolate Reductase and Thymidylate Synthase by Methotrexate Polyglutamate Analogues Lacking "Internal" a-Carboxyl Groups
The Antifolate Activity of Poly-?-Glutamyl Derivatives of Methotrexate, 10-Deazaaminopterin and 10-Ethyl-10 Deazaaminopterin
Polyglutamation of the Thymidylate Synthase Inhibitor, N⊃&10&/sup&-Propargyl-5,8-Dideazafolic Acid (CB 3717), in Organs of Ehrlich Ascites Carcinoma-Bearing Mice
5,8-Dideazafolates as Substrates for Folypoly-?-Glutamate Synthetase from Pig Liver
5-Substituted-5-Deaza Analogues of Classical Antifolates
Azido-Substituted Antifolate Drugs: Synthesis, Structure, and Activity
Summary: Novel Antifolates
Author Index
Subject Index
List of Participants

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