This thesis describes the development of biophysically detailed computer models of the human atria and torso to study the underlying mechanisms of cardiac diseases, some of the most common causes of morbidity and mortality. This is a cross-disciplinary project, involving fundamentals of cardiac electrophysiology, physics of excitable media, applied mathematics and high performance scientific computing and visualisation. The author uses computer models to provide insights into the underlying mechanisms of the genesis of atrial fibrillation and develops novel techniques for the monitoring of atrial tachycardia.
Reihe
Auflage
Sprache
Verlagsort
Verlagsgruppe
Springer International Publishing
Illustrationen
95
42 farbige Abbildungen, 95 s/w Abbildungen
XXII, 256 p. 137 illus., 42 illus. in color.
Dateigröße
ISBN-13
978-3-319-01643-6 (9783319016436)
DOI
10.1007/978-3-319-01643-6
Schweitzer Klassifikation
Introduction.- Background.- Development of a new model for simulating the electrical action potentials of human atrial myocytes.- Development of a family of regional cell models.- Autonomic regulation and pathophysiological remodelling.- 3D Anatomical Modelling of the Atria.- Pacemaking and autonomic regulation in the 3D sinoatrial node and atria.- Atrial Fibrillation.- Discussion.
