Natural Products in Chemical Biology

Preface vii
Contributors ix
PART I CHEMICAL DIVERSITY OF NATURAL PRODUCTS 1
1 Plant Natural Products 3
A. Leslie Gunatilaka
2 Marine Natural Products 31
Nobuhiro Fusetani
3 Microbial Natural Products 65
Sergio Sanchez, Silvia Guzma´n-Trampe, MarianaA´valos, Beatriz Ruiz, Romina Rodr´yguez-Sanoja, andManuel Jim´enez-Estrada
PART II BIOSYNTHESIS OF NATURAL PRODUCTS 109
4 Nonribosomal Peptides 111
Georg Schoenafinger and Mohamed A. Marahiel
5 Plant Terpenoids 127
Christopher I. Keeling and J¨org Bohlmann
6 Polyketides in Fungi 143
Thomas J. Simpson and Russell J. Cox
7 Modular Polyketide Synthases 163
Tonia J. Buchholz, Jeffrey D. Kittendorf, and David H.Sherman
8 Polyketide Polyethers 189
Alison M. Hill
9 Alkaloids 209
Sarah E. O'Connor
10 Cofactors 239
Ilka Haase, Markus Fischer, Adelbert Bacher, WolfgangEisenreich, and Felix Rohdich
11 Antibiotics 269
Sergey B. Zotchev
PART III NATURAL PRODUCTS IN MEDICINE 287
12 Pharmaceuticals: Natural Products and Natural Product Models289
Sheo B. Singh
13 Natural Products as Anticancer Agents 325
David G. I. Kingston and David J. Newman
14 Plant-Derived Natural Products Research in Drug Discovery351
Kuo-Hsiung Lee, Hideji Itokawa, Toshiyuki Akiyama, and Susan L.Morris-Natschke
Index 389