Neuroblastoma is a medical enigma. As a childhood neoplasm arising from neural crest cells, it is characterized by diverse clinical behaviors ranging from spontaneous remission to rapid tumor progression and death. Although clinical outcome can be predicted to a large extent by the stage of disease and the age at diagnosis, an in-depth understanding of its clinico-pathological behavior, now greatly aided by sophisticated molecular genetic profiling, will improve diagnostic precision and refine risk-based therapies. Comprehensive international efforts have advanced our understanding of tumor biology and improved the clinical management of children with neuroblastoma. This book reviews our current understanding of the genes and biological pathways that contribute to neuroblastoma pathogenesis, modern risk-based treatment approaches for these patients, and recent advances in biologically based therapy. It provides a concise up-to-date reference for practitioners, students, and researchers.
Rezensionen / Stimmen
From the reviews:
"This comprehensive, multiauthored book describes the epidemiologic, genetic, biologic, pathologic, diagnostic and therapeutic aspects of neuroblastoma in 19 concise, informative chapters. . Production is excellent with clear illustrations and helpful tables. . those with an interest in cancer investigation and whose consultations include a number of pediatric cancer patients, this excellent book illuminates scientific, diagnostic, and treatment issues that will increase their understanding of neuroblastoma and of the difficulties encountered in combating this and other childhood neoplasms. Overall grade: Outstanding." (B. D. Fletcher, Pediatric Radiology, Vol. 36, 2006)
