Epigenetic Drug Discovery

- Introduction to Drug Discovery in Epigenetics

- Assay Development and Screening Strategies for Epigenetic Targets

- Mass Spectrometry and Chemical Biology Approaches for Deconvoluting Epigenetic Targets

- Recent Developments in the Structural Mechanism of Protein Methyltransferase Inhibition

- Epigenomic Sequencing Technologies

- Safety Consideration of Targeting Epigenetic Mechanisms

- Toward Understanding Pharmacological Modulation of DNA Methylation and Its Effects on Gene Expression

- Histone Deacetylases

- Chemical Targeting of Histone Acetyltransferases

- Histone Lysine Methyltransferases

- Inhibiting Arginine Methylation

- Histone Demethylases

- Targeting the Human Acetylation Reader Family: Bromodomain Proteins

- Targeting Histone Readers: Non-bromodomain Readers

- Arising Opportunities and Challenges of Targeting Chromatin Remodelers

- RNA Modifying Proteins: Emerging Targets for Drug Discovery

- Directly Targeting RNA with Drug-like Small Molecules

- Discovery and Development of Tazemetostat

- Menin Inhibitors: Discovery, Development and Clinical Translation

- Discovery of MTA-cooperative PRMT5 Inhibitors