Handbook of Proteases in Cancer

I. General Aspects

1.1. Influence of Serine Proteases on Bone Morphogenetic Proteins: Insights for Advancing Treatment Paradigms in Breast Cancer

Anmol Kapoor, Chandi C. Mandal

1.2. Proteases in Cancer Theranostics

Deepmala Karmakar, Sanghamitra Sengupta

1.3. Structural aspects of proteases in cancer therapeutics: A perspective

Anirban Nandy, Sima Biswas, Angshuman Bagchi

II. Proteases in Cancer Therapy

2.1 Ubiquitin specific proteases: The role and potential in cancer immunotherapy

Bee Ling Tan1, Ayman El-Meghawry El-Kenawy2,3, Yin Sim Tor4

2.2. Proteasome, the recycle bin of the cancer cell

Amy Dunne Miller1, Vasudha Tandon1, Nilabja Sikdar2, Sourav Banerjee1

2.3. The role of caspase 3 in post chemotherapy breast and colorectal cancer relapse and metastasis.

Andreja Leskovac, Sandra Petrovic

2.4. Role of Serine Proteases in Gastric Cancer: Inhibition and Cure

Reena Kumari1,2, Kshetrimayum Birla Singh2, Amit Kumar Rai1,

Sivakumar Vijayaraghavalu2*

2.5. Serine protease inhibitors in breast cancer therapy

Abinaya Elango, Arunkumar Radhakrishnan*

2.6. Serine proteases in cancer: Mechanisms and treatment options

Madhu Tanya Singh; Ammu V. V. V. Ravi Kiran; Garikapati Kusuma Kumari; Praveen T. Krishnamurthy*

2.7. Survivin, a moonlighting caspase inhibitor and potential oncotherapeutic target
Abdul Basit Baba1, Rajakishore Mishra2, Siddavaram Nagini3

2.8. Ubiquitin-specific proteases for the treatment of breast cancer

Suchetana Pal1, Subhasish Sarkar2, Rajlakshmi Laha2, Somasri Dam

2.9. Microbial secretory proteases: a new insight in the field of cancer therapies

Nanda Singh, Rima Tapader, Amit Pal

2.10. The emerging role of the ?-secretase inhibitors in cancer management

Anuj Kumar Borah1, Chongtham Sovachandra Singh1, Babiangshisha Kharbuli1, Anupam Chatterjee2, Subhendu Chakrabarty3, Amlan Das1

2.11. Cathepsins in cancer therapy and precision medicine

Namrata Singh1*, Aqsa Khan2, Asma Mohin Rojewale1, Shinjinee Sengupta2

2.12. The Emerging Role of Calpain 2 Protease as a Therapeutic Target in

Breast Cancer

Praveen Kumar Chandra Sekar1, Jayakumar Subramaniyan2, Ramakrishnan Veerabathiran1*

III. Epigenetic Tools and Stem Cell Therapy

3.1. Calpains, miRNA and cancer: an overview

Sajal Chakraborti1*, Mahasweta Ghosh1, Rajabrata Bhuyan2, Dibyapriya Roy Chowdhury1, Tapati Chakraborti1

3.2. The roles of ubiquitin-specific proteases (USPs) in cancer stem cell maintenance.

Kuan Ping Anga2, Won Fen Wonga3, Chung Yeng Looi

3.3. Modulatory Effects of Stem Cell Therapy on Cysteine Proteases and Matrix Metaloproteases in Breast Cancer

Nour Y. S. Yassin, Noha A. Ahmed, Manal N. Abdel Azeem, Osama M. Ahmed

3.4. Application of metalloproteases in cancer stem cell therapy

Uju Dorathy Iliemene1*, Paul T. Olonishuwa1, and Mubarak Labaran Liman2

3.5. Regulatory Mechanisms and Clinical Potential of Epigenetic Targeting in Glioma

Yetirajam Rajesh, Suvendu Nandi, Priya Ghosh, Mahitosh Mandal*

3.6. Associations of proteases and long non-coding RNAs in cancer

Gaurav Kumar Bhagat1, Dipanjan Guha2, Angshuman Bagchi

3.7. Stem cell-mediated interventions in cancers caused by proteases

Farheen Showkata2, Sabra Parveena2, Neetu Badesraa2, Mohmmad Saleem Dar1,2, Md Mehedi Hossaina2, Mir Owais Ayaz1,2, Mohd Jamal Dar1,2

3.8. Stem cell therapy in bone marrow cancer

Arjun K R, Girish Kanavi K, Sudipta Choudhury, Mythreyi R, Kanthesh M Basalingappa

IV. Nanotechnology Based Therapies

4.1. Protease-targeting nanoparticles for cancer therapy and imaging

Sandra Petrovic*, Andreja Leskovac

4.2. Nanomedicine role in proteolytic landscape of breast cancer

Sobia Noreen1, Mehwish Ishtiaq1, Sara Hasan1,2, Shazia Akram Ghumman3, Samina Aslam4

4.3. Proteasome Inhibitors and Nano-Delivery Systems for Therapy of Glioblastoma Multiforme

Mekala Janaki Ramaiah1, Sahiti Chamarthy1, Janumala Mary Edna1, Katari Sukeerthi2, Nallapaty Srilakshmi2, Prasanna Srinivasan Ramalingam3, Sivakumar Armugam3

4.4. Emerging proteases for molecular imaging and therapy in cancer

Presenjit1,2, Shubhra Chaturvedi1, Vishaka Chaudhary1,3, V.P. Singh4, Kaman Singh2, A.K. Mishra1*

4.5. Novel nano technologies associated with Car-T cell therapy in breast cancer

Avipsa Hazra1, Ragini Khanna2, Parthiban R3, Gopenath TS4,

Kanthesh BM1*

V. Bioinformatics and System Biology

5.1. System biology approach of protease Cathepsin K in glioblastoma multiforme

Prasanna Srinivasan Ramalingam1, Sivakumar Arumugam1, Purushothaman Balakrishnan2, Janaki Ramaiah Mekala

5.2. Omics technologies for matrix metalloproteinases: MMPs as cancer biomarkers

Sherlin Rosita Arockiaraj1, Jay Shree Mathivanan1, Shivani Jambulingam1, Karnati Balaji2, Mahima Bhardwaj2, Pushparaj Annadurai3, Thomas Jebastin1, Abhinav Parashar4, Daniel A. Gideon5*

5.3. Designing Novel Serine Protease Inhibitors against Potential Biomarkers specific to Lung Adenocarcinoma through Systems Biology and Structural Bioinformatics Approaches

Anamika Mishra1, Aniket Naha2*, Soundharya H1, Soumitra Nath3*, Nibu Varghese4, Soumya R S5

5.4. System biology and bioinformatics approaches in HTLV-1 protease targeting adult T-cell leukemia disease

Chandrabose Selvaraj1, Sanjeev Kumar Singh2, Devadasan Velmurugan

5.5. Protease profiling in lung cancer using bioinformatics tools

Protease Profiling in Lung Cancer using Bioinformatics Tools

Gowrav Baradwaj, Avipsa Hazra, Dhanu AS and Kanthesh M Basalingappa