The Carcinogenicity of Mineral Fibres.- 1. Human Studies.- Gaps in Knowledge of Fibre Carcinogenesis: an Epidemiologist's View.- Health Effects of Insulation Wools (Rock/Slag Wool and Glass Wool) and Future Research Needs.- Non-Asbestos Fibre Burden in Individuals Exposed to Asbestos.- Influence of Long-Lasting Asbestos Exposure on Immunological Status of Asbestos Exposed Shipyard Workers.- 2. Animal Studies.- Mesotheliomas in Man and Experimental Animals.- Experimental Studies on Mineral Fibre Carcinogenesis: an Overview.- The Relevance of Animal Bioassays to Assess Human Health Hazards to Inorganic Fibrous Materials.- Relative Intrinsic Potency of Asbestos and Erionite Fibers: Proposed Mechanism of Action.- Histopathological Analysis of Tumour Types after Intraperitoneal Injection of Mineral Fibres in Rats.- Radiation-Induced Mesotheliomas in Rats.- Physical and Chemical Properties.- 1. Fibre Size and Chemistry.- Carcinogenic Effect Related to the Fiber Physics and Chemistry.- Fibre Size and Chemistry Effects In Vitro and In Vivo Compared.- Inflammation and Immunomodulation Caused by Short and Long Amosite Asbestos Samples.- Fiber Dimensions and Mesothelioma: a Reappraisal of the Stanton Hypothesis.- Acute Pulmonary Effects of Inhaled Wollastonite Fibers are Dependent on Fiber Dimensions and Aerosol Concentrations.- Toxicological Aspects of the Pathogenesis of Fiber-Induced Pulmonary Effects.- Durability of Various Mineral Fibres in Rat Lungs.- Health-Related Aspects of the Heating of Refractory Ceramic Fibre.- Analysis of Polycyclic Aromatic Hydrocarbons on Vapor-Grown Carbon Fibers.- Induction of Inflammation and Fibrosis after Exposure to Insoluble and Isometric Particles.- 2. Minerology.- Association of Tremolite Habit with Biological Potential: PreliminaryReport.- Distinguishing between Amphibole Asbestos Fibers and Elongate Cleavage Fragments of their Non-Asbestos Analogues.- Asbestiform Minerals Associated with Chrysotile from the Western Alps (Piedmont - Italy): Chemical Characteristics and Possible Related Toxicity.- Mechanisms of Pathogenesis.- 1. Genotoxic Effects.- Mechanisms of Fibre Genotoxicity.- Asbestos Carcinogenicity: a Mutational Hypothesis.- The Mutagenicity of Mineral Fibers.- Chromosomal Damage and Gap Junctional Intercellular Communication in Mesothelioma Cell Lines and Cultured Human Primary Mesothelial Cells Treated with MMMF, Asbestos and Erionite.- Chrysotile, Crocidolite, and Anthophyllite Facilitation of Transfection of Cultured Mouse Cells by Polyomavirus DNA.- 2. Effects on Gene Expression.- Asbestos Mediated Gene Expression in Rat Lung.- Rat Pleural Cell Populations: Effects of MMMF Inhalation on Cytokine mRNA Expression and Population Characteristics.- Growth Factor and Growth Factor Receptor Expression in Transformed Rat Mesothelial Cells.- 3. Fibres and Free Radicals.- The Surface Activity of Mineral Dusts and the Process of Oxidative Stress.- Iron Mobilization from Crocidolite Results in Enhanced Iron-Catalyzed Oxygen Consumption and Hydroxyl Radical Generation in the Presence of Cysteine.- The Role of Iron in the Redox Surface Activity of Fibers. Relation to Carcinogenicity.- Chemical Functionalities at the Broken Fibre Surface Relatable to Free Radicals Production.- Reactive Oxygen Metabolite Production Induced by Mineral Fibres.- Oxygen Consumption, Lipid Peroxidation and Mineral Fibres.- Effects of Cigarette Smoke on Uptake of Asbestos Fibres by Tracheal Organ Cultures: the Role of Active Oxygen Species.- 4. Other Effects and Promotion.- Promoting Effects of Fibres. Fibres and theSecond Messenger Pathways.- Apparent Promotion by Chrysotile Asbestos of NHMI-Initiated Lung Tumours in the Rat.- Effects of Amosite Asbestos Fibers on the Filaments Present in the Cytoskeleton of Primary Human Mesothelial Cells.- A Comparison of the Occurrence and Distribution of Iron Deposits Caused by the Presence of Intrapleural Erionite and Crocidolite Fibres in Rats.- Secretion of Interleukin-1 and Tumour Necrosis Factor by Alveolar Macrophages Following Exposure to Particulate and Fibrous Dusts.- Cultured Human Mesothelial Cells are Selectively Sensitive to Cell Killing by Asbestos and Related Fibers: a Potential In Vitro Assay for Carcinogenicity.- Human Risk Asessment.- Animal and Cell Models for Understanding and Predicting Fibre-Related Mesothelioma in Man.- Chronic Inhalation Toxicity of Refractory Ceramic Fibers in Syrian Hamsters.- A Classification System for Non-Asbestiform Fibres.- Tumours by the Intraperitoneal and Intrapleural Routes and their Significance for the Classification of Mineral Fibres.- Fibre Carcinogenesis: Intra-Cavitary Studies Cannot Assess Risk to Man.- Author Index.
