Insulin, chemistry, structure, and function of insulin and related hormones

Name: Insulin, chemistry, structure, and function of insulin and related hormones | Proceedings of the Second International Insulin Symposium, Aachen, Germany, September 4-7, 1979
Brand: De Gruyter
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Proceedings of the Second International Insulin Symposium, Aachen, Germany, September 4-7, 1979

Dietrich Brandenburg Axel Wollmer(Herausgeber*in)

De Gruyter (Verlag)

1. Auflage

Erschienen am 20. Mai 2019

XVIII, 752 Seiten

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Inhalt

Intro
ACKNOWLEDGEMENTS
Preface
CONTENTS
INTRODUCTION
SECTION I. STRUCTURE OF INSULIN
A Comparison Between the Insulin Molecules in 2-Zinc and 4-Zinc Insulin Crystals
Crystal Structure, Aggregation and Biological Potency of Beef Insulin Cross-Linked at A1 and B29 by Diaminosuberic Acid
Correlation of Structural Details of Insulin in the Crystal and in Solution
SECTION II. PEPTIDE SYNTHESIS
An Assessment of Protecting Group Strategies in Synthesis of Large Peptides
Fully Active Semisynthetic Insulin by Selective Formation of the Disulfide Bridges as an Intermediate Result of the Total Synthesis by Fragment Condensation on Polymer Phase
[A14-Phenylalanine-Insulin]: A Synthetic Analogue
[B25-Tyrosine]B-Chain-S-Sulfonate of Porcine Insulin
The Synthesis of [B25-4-Nitrophenylalanine]-Octapeptide B(23-30) of Porcine Insulin
A Novel Route for the Preparation of Mono-Iodotyrosine and Mono-Iodotyrosine-Containing Peptides by Electrochemical Reduction of Di-Iodo Derivatives
Alternative Approach for Human Proinsulin Synthesis
An Alternative Synthesis of Glucagon by the Method of Solid Phase Condensation of Peptide Fragments
SECTION III. SEMISYNTHESIS AND CHEMICAL MODIFICATION
Progress Towards the Semisynthesis of Preproinsulin
Specific Activation of the Arginine Carboxyl Group of the B-Chain of Bovine Des-Octapeptide-(B23-30)-Insulin
Enzyme-Catalyzed Semisynthesis with Insulin Derivatives
The Relative Reactivity of Insulin Amino Groups as an Indicator of Structural Accessibility and its Use for Synthetic Approaches for Structure-Function Studies
A14-(N-Methylpyridinium) and A14-(2-Nitro-4-Trimethylammoniophenyl) Derivatives of Bovine Insulin
Preparation of Covalent Insulin Dimers
Reactions of Insulin Derivatives with ETAC Reagents
SECTION IV. RADIOACTIVE LABELLING AND SEPARATION TECHNIQUES
The Application of HPLC to the Analysis of Radio- Iodinated Tracers of Glucagon and Insulin
Monoiodoinsulin Specifically Substituted in A14-Tyr or A19-Tyr
Preparation of Homogeneous Insulin Tracers with Monoand Di-Iodo-Desaminotyrosines in Position B1
Insulin and Proteins Labeled by Microwave Discharge Activation of Tritium
Radioactive Labelling (⊃&14&/sup& C, ⊃&3&/sup& H) of Insulin and Insulin Derivatives by Reductive Methylation
Isolation of Homogeneous N, N-Di-Methylated Derivatives
Quantitative Determination of Insulin by Gradient Elution HPLC
Some Preliminary Findings in Isotachophoretic Analyses of Insulin
Studies on the Denaturation of Dissolved Insulin
SECTION V. RECEPTORS AND HORMONE-RECEPTOR INTERACTION
⊃&125&/sup& I-SpHPP-Avidin: A Tool for Hormone Receptor Studies
Chromatographic Properties of the Adipocyte Transport System in Detergent Solution and its Resolution from the Insulin Receptor
Hydrophobic Interaction Chromatography as a Tool in Insulin Receptor Purification
Localization of Insulin-Receptor Complexes on the Surface of Whole Cells by Autoradiography
Insulin Receptors in the Heart Muscle: Evidence for the Negative Cooperativity Binding Model
Insulin Receptors, Insulin Degradation, and Biological Activity
Gammeltoft, S.#Kristensen, L.Ø.
Regulation of Insulin Receptors in Isolated Hepatocytes from Normal and Streptozotocin-Diabetic Rats in the Fed and 48 H Fasted State
Insulin-Receptor Turnover and Down Regulation
Receptor-Mediated Internalisation of Insulin, Glucagon and Growth Hormone in Intact Rat Liver. A Biochemical Study
Kinetics of Insulin Binding to Its Receptors in vivo. Effects of Fasting
Hystricomorph Insulins and Insulin Receptors
SECTION VI. PHOTO-INDUCED HORMONE-RECEPTOR COUPLING
Photoreactive Insulin Derivatives: Preparation and Characterization
Photoreactive Insulin Derivatives: Chemical and Physical Properties
The Preparation and Application of an A1-Substituted Photo-Reactive Insulin Analogue
Photoaffinity Labeling of Insulin Receptor Proteins of Liver Plasma Membranes
Characterisation of Insulin Binding Sites in Rat Liver Plasma Membranes Using Photoreactive Insulin Analogues
Permanent Activation of Lipogenesis by Insulin Covalently Bound to Adipocyte Receptors
SECTION VII. STRUCTURE, BINDING, ACTIVITY
The Activation of Adenylate Cyclase by Chemically Modified Forms of Glucagon and its Relationship to Receptor Binding
Structure-Activity Relationships of Insulin-Induced Negative Cooperativity Among Receptor Sites
Properties of a Mutant Insulin Species Causing Human Diabetes
A1-Modified Insulins: Receptor Binding and Biological Activity
Biological Activity of Insulin Analogues Substituted at the Amino Group of B1-Phenylalanine
Functional Role of the N-Terminal Region of the B-Chain of Insulin
Biological Properties of Covalent Insulin Dimers
Biological Activity and Receptor Binding of Six Different Covalent Dimers of Insulin
In vitro and in vivo Effects of Poly-N-Vinylpyrrolidone- Insulin
Study of Insulin Action by Use of Insulin-Dextran Complex: Uptake of Insulin into Subcellular Fractions and Stimulation of Pyruvate Dehydrogenase in Mouse Adipocytes
Studies on the Mechanism of Insulin Action VI: The Interaction of Insulin Fragments with Insulin Receptor
Stimulation of Intracellular H⊂&2&/sub& 0⊂&2&/sub& Production in Rat Epididymal Adipocytes by Insulin, Insulin Fragments, and Other Hormones and Growth Factors with Insulin-Like Activities
Early Events in Insulin Binding and Insulin Action in Fat Cells and Hepatocytes
Role of the Biodegradation Process in the Action of Insulin. A Proposal for a Model Consisting of Sulfhydryl- Disulfide Interchange Reaction and Proteolysis
Insulin Receptors, Receptor Antibodies and the Mechanism of Insulin Action
SECTION VIII. DEGRADATION
Studies on Uptake of [⊃&3&/sup& H]-Insulin by Erythrocytes
An Insulin-Degrading Enzyme from Human Erythrocytes: Isolation and Characterization
Comparison of⊃& 125 &/sup&I-Insulin and [B1- 3 H-Phenylalanine]- Insulin Degradation by Insulin Protease
The Chemical Characterization of the Products of the Processing of Subcutaneously Injected Insulin
Some Inhibitors of Insulin Degradation
Excretion of Endogenous and Exogenous Insulin by Kidney in Diabetic Ketoacidosis
Incubation of Insulin in Hyperglycemic Blood Generates Insulin Dimers
SECTION IX. IMMUNOLOGY
Genetic Regulation of the Immune Response of Mice to Insulins of Different Species
Genetic Control of the Immune Response to Insulin
Analysis of the Immunogenicity of Three Insulin- Preparations
Studies on the Immunological Properties of Natural and Modified Insulins
Genetic Control of the Immune Response to Insulin: A Clinical Study of Adverse Immunologic Reactions to Insulin
The Induction of Hyperglycemia with Insulin Antibodies to B-Chain Determinants
The Pattern of B-Lymphocyte Specificities for Modified and Unmodified Insulins in the Mouse
Specificity of Rabbit Anti-Insulin Antibody
Radioimmunoassay of Chemically-Modified Insulins - Use and Misuse
Purity of Chromatographycally Purified Insulins Measured by Skin-Reactivity and Insulin-Specific IGE
SECTION X. BIOSYNTHESIS, STORAGE, EVOLUTION
Human Preproinsulin: Primary Structure of the Messenger RNA
Quantification of Proinsulin Biosynthesis by Determination of Specific Radioactivity of [⊃&3&/sup& H]-Leucine in Pancreatic Islets
Immunoreactive Rat C-Peptides I and II in Glucose Perfusate of Isolated Pancreas
Biosynthesis of Somatostatin in Pancreatic Islets of Wistar Rats
Crystallography of Intracellular Insulin and Glucagon as Revealed by Investigations of Tissues and Models
Pancreatic Hormone Storage Granules: The Role of Metal Ions and Polypeptide Oligomers
On the Molecular Biology of Hagfish Insulin
SECTION XI. INSULIN-RELATED HORMONES
Possible Relationships in the Processing, Storage and Secretion of Some Insulin-Related Peptides
Insulin-Like Growth Factors
Relaxin and Relaxin-Like Peptides in Ovaries of Pregnant Sows and Sharks
Structural Studies on Porcine Relaxins and their Biosynthetic Precursors
PRESENTATIONS NOT INCLUDED IN THIS VOLUME
LIST OF PARTICIPANTS
ABBREVIATIONS
SUBJECT INDEX
AUTHOR INDEX

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