A central problem in neurobiology concerns mechanisms that generate the pro found diversity and specificity of the nervous system. What is the substance of diversification and specificity at the molecular, cellular, and systems levels? 4 How, for example, do 1011 neurons each form approximately 10 interconnec tions, allowing normal physiological function? How does disruption of these processes result in human disease? These proceedings represent the efforts of molecular biologists, embryologists, neurobiologists, and clinicians to approach these issues. in this volume are grouped by subject to present the varieties The chapters of methods used to approach each individual area. Section I deals with embry ogenesis and morphogenesis of the nervous system. In Chapter 3, Weston and co-workers describe the use of monoclonal antibodies that recognize specific neuronal epitopes (including specific gangliosides) for the purpose of defining heterogeneity in the neural crest, an important model system. Immunocyto chemical analysis reveals the existence of distinct sUbpopulations within the crest at extremely early stages; cells express neuronal or glial binding patterns at the time of migration. Consequently, interactions with the environment may select for predetermined populations. Le Douarin reaches similar conclusions in Chapter 1 by analyzing migratory pathways and developmental potentials in crest of quail-
Sprache
Verlagsort
Verlagsgruppe
Illustrationen
148 s/w Abbildungen
XXVI, 363 p. 148 illus.
Dateigröße
ISBN-13
978-1-4613-2717-2 (9781461327172)
DOI
10.1007/978-1-4613-2717-2
Schweitzer Klassifikation
I. Embryogenesis and Morphogenesis of the Nervous System.- 1 A Model for Cell Line Divergence in the Ontogeny of the Peripheral Nervous System.- 2 Emergence of Neuronal and Glial Cell Lineages in Primate Brain.- 3 Heterogeneity in Neural Crest Cell Populations.- 4 The First Growth Cones in the Central Nervous System of the Grasshopper Embryo.- II. Developmental Expression of Neuraonal Phenotypic Characters.- 5 Surface-Bound and Released Neuronal Glycoconjugates.- 6 The Differentiation of Membrane Properties of Spinal Neurons.- 7 The Accumulation of Acetylcholine Receptors at Nerve-Muscle Synapses in Culture.- 8 Transmitter Phenotypic Plasticity in Developing and Mature Neurons in Vivo.- III. Nerve Growth Factor as a Model Growth Factor.- 9 Mechanisms of the Promotion of Neurite Outgrowth by Nerve Growth Factor.- 10 Cultured Sympathetic Neurons in the Study of Nerve Growth Factor Action.- 11 Guanethidine-Induced Destruction of Sympathetic Neurons: An Autoimmune "Disease" Prevented by Nerve Growth Factor.- 12 Enhanced Dependence of Fetal Mouse Neurons on Trophic Fators after Taxol Exposure in Organotypic Cultures.- 13 The Interaction of Nerve Growth Factor with Its Specific Receptors.- IV. New Neuronal Growth Factors.- 14 Multiple Sites for the Regulation of Neurite Outgrowth.- 15 Nerve Growth Factors in Chick and Rat Tissues.- 16 Macromolecular Factors Involved in the Regulation of the Survival and Differentiation of Peripheral Sensory and Sympathetic Neurons.- 17 Trophic and Neurite-Promoting Factors for Cholinergic Neurons.- V. Molecular Biology of Neural Development and Function.- 18 Expression of Opioid Peptide Genes in Different Species.- 19 Isolation and Characterization of DNA Sequences Coding for Mouse and Human ß-Nerve Growth Factor.- 20 Linkage Analysis inFamilial Dysautonomia Using Variations in DNA Sequence in the ß Nerve Growth Factor Gene Region: A Beginning.- VI. Diseases of Development.- 21 Familial Dysautonomia and Other Congenital Sensory and Autonomic Neuropathies.- 22 Developmental Neurobiology of Human Diseases: Familial Dysautonomia and Related Disorders.
