Prostaglandin research is one of the most explosive fields in the biological science, and there have been a number of international symposia on this subject. In planning the second Advanced Course in Erice (Sicily) at the "Ettore Majorana" center it was realized that large congresses might not represent the best way to facilitate communication within specialized areas of biologic and medical research. In fact small meetings where in depth discussion is confined to a limited number of scientists, are now generally considered successful vehicles of scientific information. With this in mind, we made an effort in collecting a number of experts in both experimental and clinical use of these important arachidonate metabolites. We have been very fortunate in bringing together a faculty of international authorities who contributed to the course with brilliant presentations and lively discussion. Thus, this book represents an up-to-date overview of the physiology and pharmacology of different products derived from arachidonic acid metabolism, associated with outstanding suggestions of their clinical potential. It is our hope that from this Advanced Course, and its resulting publication, new ideas concerning the physio pathological role of these compounds will arise together with new directions for future research. We are deeply indebted to NATO for its interest and generous support which made this Second Course a reality.
Reihe
Sprache
Verlagsort
Verlagsgruppe
Illustrationen
16 s/w Abbildungen
IX, 428 p. 16 illus.
Dateigröße
ISBN-13
978-1-4684-3896-3 (9781468438963)
DOI
10.1007/978-1-4684-3896-3
Schweitzer Klassifikation
Transbilayer Localization and Movement of Lysophosphatidylcholine and Phosphatidylcholine in Model - and Biomembranes.- Biosynthesis of Prostaglandins and Thromboxanes.- Phospholipases and their Relevance to Prostaglandin Biosynthesis.- Metabolism of Prostaglandins and Thromboxanes.- Basic Biochemistry of Prostaglandin Metabolism with Especial Reference to PGDH.- Assay Methods for Prostaglandins and Thromboxanes: Gas Chromatographic - Mass Spectrometric Methods and Radioimmunoassay.- Bioassay of Prostacyclin and Thromboxane A2.- Pharmacological Interference in Arachidonic Acid Cascade.- Prostaglandin System and Inflammation.- Free Radical Reactions in Relation to Lipid Peroxidation Inflammation and Prostaglandin Metabolism.- Prostaglandins and Inflammatory Hyperalgesia.- A Discussion on the Mode of Action of Non-Steroid Anti-Inflammatory Drugs: Inhibition of Prostaglandin Synthesis.- Steroidal Anti-Inflammatory Drugs.- Inhibition of Prostaglandin Biosynthesis by Anti-Inflammatory Steroids.- Prostaglandins and Immunity.- Prostacyclin.- Prostacyclin as an Anti-Atherosclerotic Hormone - A Hypothesis.- Prostaglandin Mechanisms in Blood Pressure Regulation and Hypertension.- Prostaglandins and the Regulation of Renin Release: Prostaglandins and the Regulation of Extracellular Fluid Volume.- Gender Differences in the Effect of Arachidonate Metabolites.- Prostaglandin Analogs that Antagonize the Vascular Responses to Particular Prostaglandins.- Prostaglandins and the Uterine Circulation.- Gonadal Function.- Regulation of Prostaglandin F2? Release from the Uterus during the Estrous Cycle.- Action of Prostaglandins and Other Arachidonic Acid Metabolites on Airway Function.- Arachidonic Acid Metabolism in the Lungs: Effect of Histamine and Slow-Reacting-Substance ofAnaphylaxis.- Identification and Distribution of Arachidonic Acid Metabolites in the Human Gastrointestinal Tract, and the ways in which some of these affect the Longitudinal Muscle.- Prostanoid Agonists and Antagonists: Differentiation of Prostanoid Receptors in the Gut.- Cytoprotection and Enteropooling by Prostaglandins.- Interactions between Aspirin and Other Compounds in Analgesic Medicines on Gastric Mucosal Damage in Rats.- Prostaglandins in relation to Carcinomas in Man and Laboratory Animals.
